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CYP705A5 cytochrome P450, family 705, subfamily A, polypeptide 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834850, updated on 18-Sep-2024

Summary

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Official Symbol
CYP705A5
Official Full Name
cytochrome P450, family 705, subfamily A, polypeptide 5
Primary source
TAIR:AT5G47990
Locus tag
AT5G47990
See related
Araport:AT5G47990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
cytochrome P450; family 705; MDN11.4; MDN11_4; polypeptide 5; subfamily A; THAD; THAD1; THALIAN-DIOL DESATURASE
Summary
Encodes an endomembrane system-expressed member of the CYP705A family of cytochrome P450 enzymes. It appears to catalyze the addition of a double bond to thalian-diol at carbon 15. Reduced levels of THAD expression lead to a build up of thalian-diol in root extracts. thad1-1 mutants also have longer roots than wild type seedlings and show altered gravitropic responses.
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Genomic context

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See CYP705A5 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
2
Sequence:
Chromosome: 5; NC_003076.8 (19434758..19436749)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene ncRNA Neighboring gene cytochrome P450, family 708, subfamily A, polypeptide 2 Neighboring gene thalianol synthase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gravity Persistent Signal 1 (GPS1) reveals novel cytochrome P450s involved in gravitropism. Withers JC, et al. Am J Bot, 2013 Jan. PMID 23284057
  2. Metabolic diversification--independent assembly of operon-like gene clusters in different plants. Field B, et al. Science, 2008 Apr 25. PMID 18356490
  3. Formation of plant metabolic gene clusters within dynamic chromosomal regions. Field B, et al. Proc Natl Acad Sci U S A, 2011 Sep 20. PMID 21876149, Free PMC Article
  4. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article
  5. Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics. Bellati J, et al. Mol Cell Proteomics, 2016 Nov. PMID 27609422, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_124173.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables thalian-diol desaturase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within flavonol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive gravitropism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thalianol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
cytochrome P450, family 705, subfamily A, polypeptide 5
NP_199610.1
  • ''cytochrome P450, family 705, subfamily A, polypeptide 5'' (CYP705A5); FUNCTIONS IN: oxygen binding, thalian-diol desaturase activity; INVOLVED IN: thalianol metabolic process, root development; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: hypocotyl, root, callus; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 705, subfamily A, polypeptide 32 (TAIR:AT3G20950.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    19434758..19436749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124173.3 → NP_199610.1  cytochrome P450, family 705, subfamily A, polypeptide 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199610.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FI39
    UniProtKB/TrEMBL
    A0A178UGC2, A0A654G992
    Conserved Domains (1) summary
    cd20655
    Location:75 → 504
    CYP93; cytochrome P450 family 93
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FI39.1

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