Fstl3 follistatin-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fstl3provided by MGI
Official Full Name: follistatin-like 3provided by MGI
Primary source: MGI:MGI:1890391
See related: Ensembl:ENSMUSG00000020325 AllianceGenome:MGI:1890391
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Flrg; E030038F23Rik
Summary: Enables activin binding activity. Acts upstream of or within negative regulation of BMP signaling pathway. Located in extracellular space. Is expressed in several structures, including brain; foregut; limb; male reproductive gland or organ; and thymus. Orthologous to human FSTL3 (follistatin like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 82.3), lung adult (RPKM 26.4) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79613108..79618464)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79777274..79782630)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FSTL3 plays a biological role in the establishment and maintenance of normal pregnancy.
Title: Follistatin-like 3, an activin A binding protein, is involved in early pregnancy loss.
FSTL3 KO lead to increased activin signaling, enhancing alpha- to beta-cell transdifferentiation in mouse islets.
Title: Activin Enhances α- to β-Cell Transdifferentiation as a Source For β-Cells In Male FSTL3 Knockout Mice.
FSTL3 is a critical mediator of exercise-dependent bone formation
Title: Follistatin-like 3 is a mediator of exercise-driven bone formation and strengthening.
Data indicate that deletion of activin antagonists follistatin-like-3 (FSTL3) results in hepatic steatosis
Title: Increased activin bioavailability enhances hepatic insulin sensitivity while inducing hepatic steatosis in male mice.
Suggest FSTL3 has a role in paracrine communication between cardiomyocytes and fibroblasts.
Title: Follistatin-like 3 mediates paracrine fibroblast activation by cardiomyocytes.
crucial roles for FSTL3 in limiting testis organ size and promoting age-related testicular regression
Title: Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor β (TGFβ) signaling is essential for testicular aging and regulating testis size.
These findings link FSTL3 and TGFbeta ligand signaling and a novel subset of the synexpression group of genes to organ/tissue-specific regulatory pathways.
Title: Synexpression group analyses identify new functions of FSTL3, a TGFβ ligand inhibitor.
These results demonstrate that body composition and glucose homeostasis are differentially regulated by FST and FSTL3 and that their combined loss is associated with increased fat mass and insulin resistance despite elevated insulin production.
Title: Follistatin and follistatin like-3 differentially regulate adiposity and glucose homeostasis.
Fstl3 as a stress-induced regulator of hypertrophy that controls myocyte size via regulation of Smad signaling.
Title: Cardiac myocyte-specific ablation of follistatin-like 3 attenuates stress-induced myocardial hypertrophy.
Fstl3 is induced in heart by myocardial stress
Title: Activin A and follistatin-like 3 determine the susceptibility of heart to ischemic injury.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (8) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info
enables activin binding	IDA Inferred from Direct Assay more info	PubMed
enables activin binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	IEA Inferred from Electronic Annotation more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: follistatin-related protein 3

Names: follistatin-like protein 3; follistatin-related gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031380.2 → NP_113557.1 follistatin-related protein 3 precursor

See identical proteins and their annotated locations for NP_113557.1

Status: VALIDATED

Source sequence(s)

AK079286, AK082898, BC061052, BQ840331

Consensus CDS

CCDS23990.1

UniProtKB/Swiss-Prot

Q9EQC7

UniProtKB/TrEMBL

Q542M9

Related

ENSMUSP00000020575.5, ENSMUST00000020575.5

Conserved Domains (2) summary

smart00280
Location:132 → 165

KAZAL; Kazal type serine protease inhibitors

cl00097
Location:169 → 229

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...