Lin28a lin-28 homolog A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lin28aprovided by MGI
Official Full Name: lin-28 homolog Aprovided by MGI
Primary source: MGI:MGI:1890546
See related: Ensembl:ENSMUSG00000050966 AllianceGenome:MGI:1890546
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lin28; Tex17; Lin-28; Gm10299; lin-28A
Summary: Enables RNA binding activity and translation initiation factor binding activity. Involved in several processes, including RNA metabolic process; cellular response to glucose stimulus; and positive regulation of intracellular signal transduction. Acts upstream of or within several processes, including miRNA metabolic process; negative regulation of glial cell differentiation; and regulation of gene expression. Located in nucleolus and rough endoplasmic reticulum. Is expressed in several structures, including early conceptus; embryo ectoderm; limb primordium; reproductive system; and tooth. Used to study nephroblastoma. Orthologous to human LIN28A (lin-28 homolog A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 6.6), CNS E11.5 (RPKM 1.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 D2.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133730641..133746504, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (134003330..134019196, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-92a-3p Knockdown Attenuates Transforming Growth Factor-beta1-induced Tubulointerstitial Fibrosis by Targeting LIN28A-mediated EMT Pathway.
Title: MiR-92a-3p Knockdown Attenuates Transforming Growth Factor-β1-induced Tubulointerstitial Fibrosis by Targeting LIN28A-mediated EMT Pathway.
Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.
Title: Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.
Dynamic nucleolar phase separation influenced by non-canonical function of LIN28A instructs pluripotent stem cell fate decisions.
Title: Dynamic nucleolar phase separation influenced by non-canonical function of LIN28A instructs pluripotent stem cell fate decisions.
Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia.
Title: Blocking the interaction between circTNRC18 and LIN28A promotes trophoblast epithelial-mesenchymal transformation and alleviates preeclampsia.
Downregulation of beta-Catenin Contributes to type II Alveolar Epithelial Stem Cell Resistance to Epithelial-Mesenchymal Transition by Lowing Lin28/let-7 Ratios in Fibrosis-Resistant Mice after Thoracic Irradiation.
Title: Downregulation of β-Catenin Contributes to type II Alveolar Epithelial Stem Cell Resistance to Epithelial-Mesenchymal Transition by Lowing Lin28/let-7 Ratios in Fibrosis-Resistant Mice after Thoracic Irradiation.
Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state.
Title: Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state.
Surface Lin28A expression consistent with cellular stress parallels indicators of senescence.
Title: Surface Lin28A expression consistent with cellular stress parallels indicators of senescence.
RNA-Binding Protein LIN28a Regulates New Myocyte Formation in the Heart Through Long Noncoding RNA-H19.
Title: RNA-Binding Protein LIN28a Regulates New Myocyte Formation in the Heart Through Long Noncoding RNA-H19.
Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice.
Title: Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice.
LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells.
Title: LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (100)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235058

RH125543 (e-PCR)
- UniSTS:162358

BE113056 (e-PCR)
- UniSTS:246622

G65219 (e-PCR)
- UniSTS:225887

G65793 (e-PCR)
- UniSTS:225929

Lin28 (e-PCR), detects polymorphism
- UniSTS:516862

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-quadruplex RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables pre-miRNA binding	IEA Inferred from Electronic Annotation more info
enables pre-miRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-RNA adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-RNA adaptor activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA 3' uridylation	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within miRNA metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of glial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of pre-miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of pre-miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of TOR signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell proliferation involved in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pre-miRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in pre-miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pre-miRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of miRNA-mediated gene silencing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in stem cell population maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in rough endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein lin-28 homolog A

Names: RNA-binding protein LIN-28; testis expressed gene 17; testis-expressed protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145833.1 → NP_665832.1 protein lin-28 homolog A

See identical proteins and their annotated locations for NP_665832.1

Status: PROVISIONAL

Source sequence(s)

AF521097

Consensus CDS

CCDS18761.1

UniProtKB/Swiss-Prot

Q6NV62, Q8K3Y3

Related

ENSMUSP00000050488.3, ENSMUST00000051674.3

Conserved Domains (1) summary

cd04458
Location:42 → 111

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

133730641..133746504 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250361.4 → XP_011248663.1 protein lin-28 homolog A isoform X2

Conserved Domains (2) summary

COG5082
Location:70 → 133

AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

cd04458
Location:2 → 61

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
XM_006539317.4 → XP_006539380.1 protein lin-28 homolog A isoform X1

Conserved Domains (2) summary

COG5082
Location:104 → 167

AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

cl09927
Location:60 → 96

S1_like; Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. Both domains ...