Tex11 testis expressed gene 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tex11provided by MGI
Official Full Name: testis expressed gene 11provided by MGI
Primary source: MGI:MGI:1933237
See related: Ensembl:ENSMUSG00000009670 AllianceGenome:MGI:1933237
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZIP4H; 4930565P14Rik
Summary: Involved in meiotic gene conversion and reciprocal meiotic recombination. Acts upstream of or within several processes, including male gonad development; meiotic nuclear division; and negative regulation of apoptotic process. Located in central element. Colocalizes with synaptonemal complex. Is expressed in oocyte and testis. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 2. Orthologous to human TEX11 (testis expressed 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: X C3; X 43.72 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (99882254..100103245, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (100838648..101059639, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A partial deletion within the meiosis-specific sporulation domain SPO22 of Tex11 is not associated with infertility in mice.
Title: A partial deletion within the meiosis-specific sporulation domain SPO22 of Tex11 is not associated with infertility in mice.
Tex11 regulates genome-wide recombination rates in both sexes in a dosage-dependent manner. An intronless autosomal Tex11 transgene functionally substitutes for the X-linked Tex11 gene, providing genetic evidence for the X-to-autosomal retrotransposition evolution phenomenon.
Title: TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse.
mouse spermatogonial stem cells expressed Tex11, Hpip, and Esr2 but not Esr1, and in cultured cells, TEX11 competed with Esr2 for binding to HPIP.
Title: TEX11 modulates germ cell proliferation by competing with estrogen receptor β for the binding to HPIP.
Tex11 was first identified from mouse spermatogonia and was specifically expressed in mouse testis.
Title: An abundance of X-linked genes expressed in spermatogonia.
Zip4h (Tex11), a male germ cell specific X-linked gene was isolated. Zip4h(-/Y) mutant mice were fertile. Analysis of spermatocytes revealed a delay in meiotic double strand break repair and decreased crossover formation.
Title: ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over.
TEX11 promotes initiation and/or maintenance of synapsis and formation of crossovers, and may provide a physical link between these two meiotic processes.
Title: Meiotic failure in male mice lacking an X-linked factor.
Tex11 forms discrete foci on meiotic chromosomes. Tex11 is essential for meiosis and fertility in males. Tex11 promotes both chromosomal synapsis and crossover formation in mice and may link these two meiotic processes by interacting with Sycp2 in vivo.
Title: Meiotic failure in male mice lacking an X-linked factor.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (4) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Tex11 (e-PCR), detects polymorphism
- UniSTS:546569

BB024231 (e-PCR)
- UniSTS:186173

G65213 (e-PCR)
- UniSTS:225882

G65787 (e-PCR)
- UniSTS:225924

33.seq (e-PCR)
- UniSTS:124062

45.MMHAP38FLG6.seq (e-PCR)
- UniSTS:124580

DXS7753 (e-PCR)
- UniSTS:21962

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chiasma assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic gene conversion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of developmental process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within resolution of meiotic recombination intermediates	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptonemal complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in central element	IBA Inferred from Biological aspect of Ancestor more info
located_in central element	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: testis-expressed protein 11

Names: protein ZIP4 homolog; testis-expressed sequence 11 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167997.1 → NP_001161469.1 testis-expressed protein 11 isoform 2

See identical proteins and their annotated locations for NP_001161469.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK029799, AK082794

Consensus CDS

CCDS53150.1

UniProtKB/Swiss-Prot

Q14AT2

Related

ENSMUSP00000109345.3, ENSMUST00000113716.3

Conserved Domains (2) summary

sd00006
Location:436 → 472

TPR; TPR repeat [structural motif]

pfam08631
Location:176 → 430

SPO22; Meiosis protein SPO22/ZIP4 like
NM_031384.2 → NP_113561.2 testis-expressed protein 11 isoform 1

See identical proteins and their annotated locations for NP_113561.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK029799, BC116709

Consensus CDS

CCDS30308.1

UniProtKB/Swiss-Prot

Q14AT2, Q8BUS0, Q99MW9

Related

ENSMUSP00000009814.4, ENSMUST00000009814.10

Conserved Domains (2) summary

sd00006
Location:436 → 472

TPR; TPR repeat [structural motif]

pfam08631
Location:176 → 430

SPO22; Meiosis protein SPO22/ZIP4 like