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NHX3 Na+/H+ (sodium hydrogen) exchanger 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835640, updated on 18-Sep-2024

Summary

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Official Symbol
NHX3
Official Full Name
Na+/H+ (sodium hydrogen) exchanger 3
Primary source
TAIR:AT5G55470
Locus tag
AT5G55470
See related
Araport:AT5G55470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA NA+/H+ (SODIUM HYDROGEN) EXCHANGER 3; ATNHX3; MTE17.18; MTE17_18; Na+/H+ (sodium hydrogen) exchanger 3
Summary
member of Sodium proton exchanger family
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Genomic context

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See NHX3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Sequence:
Chromosome: 5; NC_003076.8 (22469245..22472706, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene ncRNA Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene ncRNA Neighboring gene SHV3-like 1 Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AtNHX3 is a vacuolar K+/H+ antiporter required for low-potassium tolerance in Arabidopsis thaliana. Liu H, et al. Plant Cell Environ, 2010 Nov. PMID 20573049
  2. Identification of novel families of membrane proteins from the model plant Arabidopsis thaliana. Ward JM. Bioinformatics, 2001 Jun. PMID 11395435
  3. Cation Specificity of Vacuolar NHX-Type Cation/H(+) Antiporters. Bassil E, et al. Plant Physiol, 2019 Feb. PMID 30498025, Free PMC Article
  4. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NHX3 is involved in vacuolar Na+ transport and plant growth.
    Title: Cation Specificity of Vacuolar NHX-Type Cation/H(+) Antiporters.
  2. AtNHX3 is mainly vacuolar membrane localized, and is involved in mediating K+ compartmentalization and homeostasis in Arabidopsis.
    Title: AtNHX3 is a vacuolar K+/H+ antiporter required for low-potassium tolerance in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_124929.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables sodium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of pH IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Na+/H+ (sodium hydrogen) exchanger 3
NP_200358.1
  • Na+/H+ (sodium hydrogen) exchanger 3 (NHX3); CONTAINS InterPro DOMAIN/s: Na+/H+ exchanger, subfamily (InterPro:IPR004709), Cation/H+ exchanger, conserved region (InterPro:IPR018422), Cation/H+ exchanger (InterPro:IPR006153), Na+/H+ exchanger, isoforms 1-4, conserved region (InterPro:IPR018407); BEST Arabidopsis thaliana protein match is: sodium hydrogen exchanger 2 (TAIR:AT3G05030.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    22469245..22472706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124929.3 → NP_200358.1  Na+/H+ (sodium hydrogen) exchanger 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200358.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8S397, Q9FJ63
    UniProtKB/TrEMBL
    A0A178UM68, A0A5S9YEA2
    Conserved Domains (1) summary
    TIGR00840
    Location:23 → 444
    b_cpa1; sodium/hydrogen exchanger 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8S397.2

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