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Itgae integrin subunit alpha E [ Rattus norvegicus (Norway rat) ]

Gene ID: 83577, updated on 27-Nov-2024

Summary

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Symbol
Itgaeprovided by RGD
Full Name
integrin subunit alpha Eprovided by RGD
Primary source
RGD:621644
See related
EnsemblRapid:ENSRNOG00000046639 AllianceGenome:RGD:621644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Located in cell surface. Orthologous to human ITGAE (integrin subunit alpha E). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 75.0), Spleen (RPKM 61.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Itgae in Genome Data Viewer
Location:
10q24
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (58203331..58262606)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57704813..57764093)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59652324..59711885)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1 Neighboring gene nuclear cap binding subunit 3 Neighboring gene histone H3 associated protein kinase Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 2-like Neighboring gene uncharacterized LOC108352105

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dominant tolerance to kidney allografts induced by anti-donor MHC class II antibodies: cooperation between T and non-T CD103+ cells. Degauque N, et al. J Immunol, 2006 Apr 1. PMID 16547225
  2. Sequence analysis of rat integrin alpha E1 and alpha E2 subunits: tissue expression reveals phenotypic similarities between intraepithelial lymphocytes and dendritic cells in lymph. Brenan M, et al. Eur J Immunol, 1997 Nov. PMID 9394838
  3. Integrin αEβ7 is involved in the intestinal barrier injury of sepsis. Sun JK, et al. Aging (Albany NY), 2022 Jan 18. PMID 35042191, Free PMC Article
  4. Phenotype and function of GM-CSF independent dendritic cells generated by long-term propagation of rat bone marrow cells. Yan H, et al. Cell Immunol, 2004 Jun. PMID 15474526
  5. The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Chae WJ, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769892, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Integrin alphaEbeta7 is involved in the intestinal barrier injury of sepsis.
    Title: Integrin αEβ7 is involved in the intestinal barrier injury of sepsis.
  2. transfer of tolerance requires the presence of both T cells and CD103(+) dendritic cells
    Title: Dominant tolerance to kidney allografts induced by anti-donor MHC class II antibodies: cooperation between T and non-T CD103+ cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
integrin alpha-E
Names
integrin alpha E1, epithelial-associated
integrin, alpha E, epithelial-associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031768.3 → NP_113956.2  integrin alpha-E precursor

    See identical proteins and their annotated locations for NP_113956.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HGH9, M0R6T8, O88341
    Related
    ENSRNOP00000065145.1, ENSRNOT00000073209.5
    Conserved Domains (3) summary
    smart00191
    Location:568 → 626
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:196 → 373
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:669 → 952
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    58203331..58262606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086945.1 → XP_038942873.1  integrin alpha-E isoform X1

    UniProtKB/TrEMBL
    O88341
    Related
    ENSRNOP00000112317.1, ENSRNOT00000168737.1
    Conserved Domains (4) summary
    smart00191
    Location:568 → 626
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:196 → 373
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:1108 → 1122
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:669 → 952
    Integrin_alpha2; Integrin alpha
Nucleotide Protein Strain
Heading Accession and Version

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