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VIN3 Fibronectin type III domain-containing protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835844, updated on 18-Sep-2024

Summary

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Official Symbol
VIN3
Official Full Name
Fibronectin type III domain-containing protein
Primary source
TAIR:AT5G57380
Locus tag
AT5G57380
See related
Araport:AT5G57380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MSF19.4; MSF19_4; VERNALIZATION INSENSITIVE 3
Summary
Encodes a plant homeodomain protein VERNALIZATION INSENSITIVE 3 (VIN3). In planta VIN3 and VRN2, VERNALIZATION 2, are part of a large protein complex that can include the polycomb group (PcG) proteins FERTILIZATION INDEPENDENT ENDOSPERM (FIE), CURLY LEAF (CLF), and SWINGER (SWN or EZA1). The complex has a role in establishing FLC (FLOWERING LOCUS C) repression during vernalization.
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Genomic context

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See VIN3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Sequence:
Chromosome: 5; NC_003076.8 (23246395..23249504, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene H[+]-ATPase 3 Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene U4/U6.U5 small nuclear ribonucleoprotein Neighboring gene AINTEGUMENTA-like 5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Binding Specificity of the PHD-Finger Domain of VIN3 Moderates Vernalization Response. Kim DH, et al. Plant Physiol, 2017 Feb. PMID 27999085, Free PMC Article
  2. Mechanisms underlying vernalization-mediated VIN3 induction in Arabidopsis. Kim DH, et al. Plant Signal Behav, 2010 Nov. PMID 21051939, Free PMC Article
  3. Vernalization-mediated VIN3 Induction Overcomes the LIKE-HETEROCHROMATIN PROTEIN1/POLYCOMB REPRESSION COMPLEX2-mediated epigenetic repression. Kim DH, et al. Plant Physiol, 2010 Oct. PMID 20671111, Free PMC Article
  4. VERNALIZATION INSENSITIVE 3 (VIN3) is required for the response of Arabidopsis thaliana seedlings exposed to low oxygen conditions. Bond DM, et al. Plant J, 2009 Aug. PMID 19392705
  5. Coordination of the vernalization response through a VIN3 and FLC gene family regulatory network in Arabidopsis. Kim DH, et al. Plant Cell, 2013 Feb. PMID 23417034, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The binding specificity of the PHD-finger domain of VIN3 plays a role in mediating a proper vernalization response in Arabidopsis.
    Title: The Binding Specificity of the PHD-Finger Domain of VIN3 Moderates Vernalization Response.
  2. VIN3 family of proteins nonredundantly functions to repress different subsets of the FLC gene family during the course of vernalization.
    Title: Coordination of the vernalization response through a VIN3 and FLC gene family regulatory network in Arabidopsis.
  3. The chain of events leading to the expression of VIN3, including changes at the chromatin level, are reported.
    Title: Mechanisms underlying vernalization-mediated VIN3 induction in Arabidopsis.
  4. VIN3 is under a constitutively repressed state, which is transiently relieved from repression only when sufficient cold is provided.
    Title: Vernalization-mediated VIN3 Induction Overcomes the LIKE-HETEROCHROMATIN PROTEIN1/POLYCOMB REPRESSION COMPLEX2-mediated epigenetic repression.
  5. During short-term cold exposure, histone H3 acetylation at the transcription start site rapidly increased, implying that it is required for VIN3 induction.
    Title: Histone acetylation, VERNALIZATION INSENSITIVE 3, FLOWERING LOCUS C, and the vernalization response.
  6. VIN3 is induced in response to hypoxic conditions, but is not induced in response to other stresses that affect redox homeostasis.
    Title: VERNALIZATION INSENSITIVE 3 (VIN3) is required for the response of Arabidopsis thaliana seedlings exposed to low oxygen conditions.
  7. VRN2 and VIN3 are part of a large protein complex that can include the PcG proteins FERTILIZATION INDEPENDENT ENDOSPERM, CURLY LEAF, and SWINGER, that is responsible for histone deacetylation at FLC and histone methylation at FLC in vernalized plants.
    Title: The Arabidopsis thaliana vernalization response requires a polycomb-like protein complex that also includes VERNALIZATION INSENSITIVE 3.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001345260.1
NM_125121.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in epigenetic regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vernalization response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vernalization response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in vernalization response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin silencing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Fibronectin type III domain-containing protein
NP_200548.2
  • VERNALIZATION INSENSITIVE 3 (VIN3); CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF1423, plant (InterPro:IPR004082), Zinc finger, PHD-type (InterPro:IPR001965), Fibronectin, type III-like fold (InterPro:IPR008957), Fibronectin, type III (InterPro:IPR003961); BEST Arabidopsis thaliana protein match is: vernalization5/VIN3-like (TAIR:AT4G30200.3); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    23246395..23249504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125121.3 → NP_200548.2  Fibronectin type III domain-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200548.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53YX0, Q9FIE3
    UniProtKB/TrEMBL
    A0A178UF19, A0A7G2FHQ8
    Conserved Domains (2) summary
    cd00063
    Location:318 → 408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07227
    Location:130 → 238
    PHD_Oberon; PHD - plant homeodomain finger protein

  2. NM_001345260.1 → NP_001332646.1  Fibronectin type III domain-containing protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1R7T397, A0A5S9YEV1, A0A654GBW4
    Conserved Domains (2) summary
    cd00063
    Location:298 → 388
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl22851
    Location:110 → 218
    PHD_SF; PHD finger superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FIE3.2

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