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GRIK2 geminivirus rep interacting kinase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836176, updated on 18-Sep-2024

Summary

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Official Symbol
GRIK2
Official Full Name
geminivirus rep interacting kinase 2
Primary source
TAIR:AT5G60550
Locus tag
AT5G60550
See related
Araport:AT5G60550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATSNAK1; geminivirus rep interacting kinase 2; MUF9.13; MUF9_13
Summary
Encodes a geminivirus Rep interacting kinase (GRIK; GRIK1/AT3G45240, GRIK2/AT5G60550). GRIKs are SnRK1 (SNF1-related kinases) activating kinases. Both GRIKs specifically bind to the SnRK1 catalytic subunit and phosphorylate the equivalent threonine residue in its activation loop in vitro.
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Genomic context

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See GRIK2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
13
Sequence:
Chromosome: 5; NC_003076.8 (24339229..24342590)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene late embryogenesis abundant protein-related / LEA protein-like protein Neighboring gene pyridoxine biosynthesis 2 Neighboring gene Defensin-like (DEFL) family protein Neighboring gene F-box and associated interaction domains-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cross-phosphorylation between Arabidopsis thaliana sucrose nonfermenting 1-related protein kinase 1 (AtSnRK1) and its activating kinase (AtSnAK) determines their catalytic activities. Crozet P, et al. J Biol Chem, 2010 Apr 16. PMID 20164192, Free PMC Article
  2. DOMAIN OF UNKNOWN FUNCTION581-9 negatively regulates SnRK1 kinase activity. Bortlik J, et al. Plant Physiol, 2024 Feb 29. PMID 37936321, Free PMC Article
  3. Arabidopsis protein kinases GRIK1 and GRIK2 specifically activate SnRK1 by phosphorylating its activation loop. Shen W, et al. Plant Physiol, 2009 Jun. PMID 19339507, Free PMC Article
  4. Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1- and mammalian AMPK-activating kinases. Shen W, et al. Plant Physiol, 2006 Dec. PMID 17041027, Free PMC Article
  5. DNA sequences from Arabidopsis, which encode protein kinases and function as upstream regulators of Snf1 in yeast. Hey S, et al. J Biol Chem, 2007 Apr 6. PMID 17237223

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GRIKs are SnRK1 activating kinases.
    Title: Arabidopsis protein kinases GRIK1 and GRIK2 specifically activate SnRK1 by phosphorylating its activation loop.
  2. Geminivirus Rep-interacting kinase 1, GRIK1 and GRIK2, interact with the geminivirus replication protein AL1 function by mediating one or more processes during early plant development and geminivirus infection by activating SNF1-related kinases. [GRIK2]
    Title: Geminivirus infection up-regulates the expression of two Arabidopsis protein kinases related to yeast SNF1- and mammalian AMPK-activating kinases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Miscellaneous features

  • Loc: 24339842-24339919 AT5G60550.uORF1
NM_125448.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to virus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
geminivirus rep interacting kinase 2
NP_200863.2
  • geminivirus rep interacting kinase 2 (GRIK2); CONTAINS InterPro DOMAIN/s: Calcium/calmodulin-dependent protein kinase kinase (InterPro:IPR020657), Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: geminivirus rep interacting kinase 1 (TAIR:AT3G45240.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    24339229..24342590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125448.4 → NP_200863.2  geminivirus rep interacting kinase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200863.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5HZ38, Q8LPG6, Q9FKJ2
    UniProtKB/TrEMBL
    A0A178UN27, A0A5S9YFZ4, A0A654GCV1, A0A7G2FHP3
    Conserved Domains (1) summary
    cd14008
    Location:113 → 370
    STKc_LKB1_CaMKK; Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HZ38.1

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