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PDIL1-4 PDI-like 1-4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836185, updated on 18-Sep-2024

Summary

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Official Symbol
PDIL1-4
Official Full Name
PDI-like 1-4
Primary source
TAIR:AT5G60640
Locus tag
AT5G60640
See related
Araport:AT5G60640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA PROTEIN DISULFIDE ISOMERASE 2; ATPDI2; ATPDIL1-4; MUP24.6; MUP24_6; PDI-like 1-4; PDI2; PROTEIN DISULFIDE ISOMERASE 2
Summary
Encodes a protein disulfide isomerase-like (PDIL) protein, a member of a multigene family within the thioredoxin (TRX) superfamily. Unlike several other PDI family members, transcript levels for this gene are not up-regulated in response to three different chemical inducers of ER stress (dithiothreitol, beta-mercaptoethanol, and tunicamycin). However, the level of transcripts for this gene is slightly elevated in atbzip60 mutants.
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Genomic context

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See PDIL1-4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Sequence:
Chromosome: 5; NC_003076.8 (24370827..24374098, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate acyltransferase 9 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene proline-rich receptor-like kinase Neighboring gene plasma membrane intrinsic protein 2;4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein disulfide isomerase-2 of Arabidopsis mediates protein folding and localizes to both the secretory pathway and nucleus, where it interacts with maternal effect embryo arrest factor. Cho EJ, et al. Mol Cells, 2011 Nov. PMID 21909944, Free PMC Article
  2. Ubiquitin-Mediated Proteasomal Degradation of Oleosins is Involved in Oil Body Mobilization During Post-Germinative Seedling Growth in Arabidopsis. Deruyffelaere C, et al. Plant Cell Physiol, 2015 Jul. PMID 25907570
  3. Endoplasmic reticulum stress activates the expression of a sub-group of protein disulfide isomerase genes and AtbZIP60 modulates the response in Arabidopsis thaliana. Lu DP, et al. Mol Genet Genomics, 2008 Sep. PMID 18574595
  4. The impact of oxidative stress on Arabidopsis mitochondria. Sweetlove LJ, et al. Plant J, 2002 Dec. PMID 12492832
  5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001203652.1
NM_125457.3
NM_180903.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in Golgi apparatus RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plastid HDA PubMed 
located_in secretory vesicle HDA PubMed 

General protein information

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Preferred Names
PDI-like 1-4
NP_001190581.1
  • PDI-like 1-4 (PDIL1-4); CONTAINS InterPro DOMAIN/s: Disulphide isomerase (InterPro:IPR005788), Thioredoxin fold (InterPro:IPR012335), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Protein disulphide isomerase (InterPro:IPR005792), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: PDI-like 1-3 (TAIR:AT3G54960.1).
NP_568926.2
  • PDI-like 1-4 (PDIL1-4); FUNCTIONS IN: protein disulfide isomerase activity; INVOLVED IN: response to oxidative stress; LOCATED IN: mitochondrion, endoplasmic reticulum, plasma membrane, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Disulphide isomerase (InterPro:IPR005788), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Protein disulphide isomerase (InterPro:IPR005792), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: PDI-like 1-3 (TAIR:AT3G54960.1); Has 27450 Blast hits to 18470 proteins in 2952 species: Archae - 294; Bacteria - 12373; Metazoa - 5455; Fungi - 1702; Plants - 2434; Viruses - 19; Other Eukaryotes - 5173 (source: NCBI BLink).
NP_851234.1
  • PDI-like 1-4 (PDIL1-4); FUNCTIONS IN: protein disulfide isomerase activity; INVOLVED IN: response to oxidative stress; LOCATED IN: mitochondrion, endoplasmic reticulum, plasma membrane, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Disulphide isomerase (InterPro:IPR005788), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Protein disulphide isomerase (InterPro:IPR005792), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: PDI-like 1-3 (TAIR:AT3G54960.1); Has 27268 Blast hits to 18617 proteins in 2977 species: Archae - 300; Bacteria - 12440; Metazoa - 5251; Fungi - 1704; Plants - 2409; Viruses - 19; Other Eukaryotes - 5145 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    24370827..24374098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180903.4 → NP_851234.1  PDI-like 1-4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851234.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LAM5, Q9FF55
    UniProtKB/TrEMBL
    A0A178UQB2, A0A5S9YFT3, A0A7G2FNZ9
    Conserved Domains (1) summary
    TIGR01130
    Location:103 → 557
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  2. NM_001203652.1 → NP_001190581.1  PDI-like 1-4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190581.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2FNZ9, F4K0F5
    Conserved Domains (5) summary
    cd02961
    Location:106 → 203
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    cd02981
    Location:211 → 310
    PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02995
    Location:379 → 481
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    TIGR01130
    Location:103 → 493
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    cl00388
    Location:322 → 389
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. NM_125457.3 → NP_568926.2  PDI-like 1-4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568926.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4K0F7
    Conserved Domains (5) summary
    cd02961
    Location:106 → 203
    PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
    cd02981
    Location:211 → 310
    PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02982
    Location:322 → 422
    PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02995
    Location:443 → 531
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    TIGR01130
    Location:103 → 531
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FF55.1

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