U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HDA18 histone deacetylase of the RPD3/HDA1 superfamily 18 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836228, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
HDA18
Official Full Name
histone deacetylase of the RPD3/HDA1 superfamily 18
Primary source
TAIR:AT5G61070
Locus tag
AT5G61070
See related
Araport:AT5G61070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
A. THALIANA HISTONE DEACETYLASE OF THE RPD3/HDA1 SUPERFAMILY 18; ATHDA18; histone deacetylase of the RPD3/HDA1 superfamily 18; MAF19.8; MAF19_8
Summary
Encodes a protein with similarity to histone deacetylases, a class of chromatin remodeling factors which act on H3/H4 histones. Expressed in roots where it appears to regulate the expression of epidermal cell fate genes controlling hair cell differentiation.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HDA18 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
8
Sequence:
Chromosome: 5; NC_003076.8 (24571095..24574387, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene histone deacetylase-related / HD-like protein Neighboring gene histone deacetylase 5 Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis. Xu CR, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16176989, Free PMC Article
  2. HDA18 affects cell fate in Arabidopsis root epidermis via histone acetylation at four kinase genes. Liu C, et al. Plant Cell, 2013 Jan. PMID 23362208, Free PMC Article
  3. Photoperiodic regulation of flowering time through periodic histone deacetylation of the florigen gene FT. Gu X, et al. PLoS Biol, 2013 Sep. PMID 24019760, Free PMC Article
  4. Structure of Arabidopsis HISTONE DEACETYLASE15. Chen CY, et al. Plant Physiol, 2020 Nov. PMID 32878973, Free PMC Article
  5. Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Pandey R, et al. Nucleic Acids Res, 2002 Dec 1. PMID 12466527, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_125500.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
histone deacetylase of the RPD3/HDA1 superfamily 18
NP_200915.2
  • histone deacetylase of the RPD3/HDA1 superfamily 18 (HDA18); CONTAINS InterPro DOMAIN/s: Histone deacetylase superfamily (InterPro:IPR000286); BEST Arabidopsis thaliana protein match is: histone deacetylase 5 (TAIR:AT5G61060.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    24571095..24574387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125500.3 → NP_200915.2  histone deacetylase of the RPD3/HDA1 superfamily 18 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200915.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LRK8
    UniProtKB/TrEMBL
    A0A178UIX1, A0A5S9YI91, A0A654GDE3
    Conserved Domains (2) summary
    COG1196
    Location:371 → 632
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl17011
    Location:64 → 416
    Arginase_HDAC; Arginase-like and histone-like hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LRK8.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools