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Cd82 Cd82 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 83628, updated on 27-Nov-2024

Summary

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Official Symbol
Cd82provided by RGD
Official Full Name
Cd82 moleculeprovided by RGD
Primary source
RGD:69070
See related
EnsemblRapid:ENSRNOG00000000047 AllianceGenome:RGD:69070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kai1
Summary
Predicted to be located in membrane. Predicted to be active in plasma membrane. Biomarker of hypertension and ovarian cancer. Orthologous to human CD82 (CD82 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 424.5), Kidney (RPKM 309.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cd82 in Genome Data Viewer
Location:
3q31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (99842748..99887298, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (79387361..79431847, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (82324344..82368846, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101602 Neighboring gene uncharacterized LOC134486408 Neighboring gene ALX homeobox 4 Neighboring gene exostosin glycosyltransferase 2 Neighboring gene uncharacterized LOC120101603

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Location of KAI1 on the short arm of human chromosome 11 and frequency of allelic loss in advanced human prostate cancer. Kawana Y, et al. Prostate, 1997 Aug 1. PMID 9254900
  2. Identification of the rat homologue of KAI1 and its expression in Dunning rat prostate cancers. Suzuki H, et al. Prostate, 1998 Dec 1. PMID 9831222
  3. The tetraspanin KAI1/CD82 is expressed by late-lineage oligodendrocyte precursors and may function to restrict precursor migration and promote oligodendrocyte differentiation and myelination. Mela A, et al. J Neurosci, 2009 Sep 9. PMID 19741124, Free PMC Article
  4. Identification of upregulated genes in the thymus of spontaneously hypertensive rats by cDNA representational difference analysis. Zhao XS, et al. Blood Press, 1998 Nov. PMID 10321446
  5. Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues. Geradts J, et al. Am J Pathol, 1999 Jun. PMID 10362791, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD82 appears to be a critical molecule in the regulation of oligodendrocyte progenitor migration and myelination.
    Title: The tetraspanin KAI1/CD82 is expressed by late-lineage oligodendrocyte precursors and may function to restrict precursor migration and promote oligodendrocyte differentiation and myelination.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CD82 antigen
Names
CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
Kangai 1 (suppression of tumerigenicity 6 prostate) CD82 antigen
Kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
kangai 1 (suppression of tumorigenicity 6), prostate
metastasis suppressor Kangai-1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429482.1 → NP_001416411.1  CD82 antigen

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZZR7, A6HNI9, Q6IN14

  2. NM_001429483.1 → NP_001416412.1  CD82 antigen

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZZR7, A6HNI9, Q6IN14

  3. NM_031797.2 → NP_113985.2  CD82 antigen

    See identical proteins and their annotated locations for NP_113985.2

    Status: PROVISIONAL

    Source sequence(s)
    BC072498
    UniProtKB/Swiss-Prot
    O70352
    UniProtKB/TrEMBL
    A0A8I5ZZR7, A6HNI9, F7EV99, Q6IN14
    Related
    ENSRNOP00000000052.6, ENSRNOT00000000052.6
    Conserved Domains (2) summary
    cd03160
    Location:106 → 228
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:24 → 255
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    99842748..99887298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234598.3 → XP_006234660.1  CD82 antigen isoform X1

    Related
    ENSRNOP00000078723.2, ENSRNOT00000097921.2
    Conserved Domains (2) summary
    cd03160
    Location:106 → 228
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:24 → 255
    Tetraspannin; Tetraspanin family

  2. XM_006234597.5 → XP_006234659.1  CD82 antigen isoform X1

    Conserved Domains (2) summary
    cd03160
    Location:106 → 228
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:24 → 255
    Tetraspannin; Tetraspanin family

  3. XM_039105948.2 → XP_038961876.1  CD82 antigen isoform X2

    UniProtKB/TrEMBL
    A6HNJ0
    Conserved Domains (1) summary
    cd03160
    Location:40 → 162
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  4. XM_039105951.2 → XP_038961879.1  CD82 antigen isoform X3

    Conserved Domains (1) summary
    cd03160
    Location:1 → 112
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  5. XM_039105953.2 → XP_038961881.1  CD82 antigen isoform X3

    Conserved Domains (1) summary
    cd03160
    Location:1 → 112
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70352.1 GenPept UniProtKB/Swiss-Prot:O70352

Gene LinkOut

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