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AGD1 ARF-GAP domain 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 836319, updated on 18-Sep-2024

Summary

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Official Symbol
AGD1
Official Full Name
ARF-GAP domain 1
Primary source
TAIR:AT5G61980
Locus tag
AT5G61980
See related
Araport:AT5G61980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARF-GAP domain 1; K22G18.9; K22G18_9
Summary
A member of ARF GAP domain (AGD), A thaliana has 15 members, grouped into four classes. AGD1 belongs to the class 1, together with AGD2, AGD3 and AGD4. Not expressed in hypocotyls and cotyledons.
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Genomic context

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See AGD1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
19
Sequence:
Chromosome: 5; NC_003076.8 (24894053..24899973)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene MEI2-like protein 1 Neighboring gene signal recognition particle-related / SRP-like protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deletion analysis of AGD1 reveals domains crucial for plasma membrane recruitment and function in root hair polarity. Yoo CM, et al. J Cell Sci, 2018 Jan 29. PMID 28646092
  2. AGD1, a class 1 ARF-GAP, acts in common signaling pathways with phosphoinositide metabolism and the actin cytoskeleton in controlling Arabidopsis root hair polarity. Yoo CM, et al. Plant J, 2012 Mar. PMID 22098134
  3. A class I ADP-ribosylation factor GTPase-activating protein is critical for maintaining directional root hair growth in Arabidopsis. Yoo CM, et al. Plant Physiol, 2008 Aug. PMID 18539780, Free PMC Article
  4. SCARFACE encodes an ARF-GAP that is required for normal auxin efflux and vein patterning in Arabidopsis. Sieburth LE, et al. Plant Cell, 2006 Jun. PMID 16698946, Free PMC Article
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. differential recruitment of AGD1 to specific plasma membrane domains is an essential component of the membrane trafficking machinery that facilitates root hair developmental phase transitions and responses to changes in the root microenvironment.
    Title: Deletion analysis of AGD1 reveals domains crucial for plasma membrane recruitment and function in root hair polarity.
  2. AGD1 functions in converging signaling pathways with phosphoinositides and actin in controlling root hair development.
    Title: AGD1, a class 1 ARF-GAP, acts in common signaling pathways with phosphoinositide metabolism and the actin cytoskeleton in controlling Arabidopsis root hair polarity.
  3. AGD1, a class I ADP ribosylation factor GTPase-activating protein, is important for maintaining straight growth in Arabidopsis root hairs.
    Title: A class I ADP-ribosylation factor GTPase-activating protein is critical for maintaining directional root hair growth in Arabidopsis.
Submit: New GeneRIF Correction

General gene information

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NM_125591.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root hair cell tip growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in root hair IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ARF-GAP domain 1
NP_201004.2
  • ARF-GAP domain 1 (AGD1); FUNCTIONS IN: ARF GTPase activator activity, zinc ion binding; INVOLVED IN: cytoskeleton organization; LOCATED IN: endocytic vesicle; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Arf GTPase activating protein (InterPro:IPR001164), Pleckstrin homology-type (InterPro:IPR011993), Ankyrin repeat-containing domain (InterPro:IPR020683), BAR (InterPro:IPR004148), Pleckstrin homology (InterPro:IPR001849), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: ARF GTPase-activating protein (TAIR:AT5G13300.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    24894053..24899973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_125591.3 → NP_201004.2  ARF-GAP domain 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_201004.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FIT8
    UniProtKB/TrEMBL
    A0A178ULW4, A0A7G2FI39
    Conserved Domains (5) summary
    cd07606
    Location:15 → 215
    BAR_SFC_plant; The Bin/Amphiphysin/Rvs (BAR) domain of the plant protein SCARFACE (SFC)
    cd13250
    Location:291 → 429
    PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
    sd00045
    Location:740 → 766
    ANK; ANK repeat [structural motif]
    cd08204
    Location:501 → 630
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    pfam12796
    Location:729 → 799
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FIT8.2

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