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Pde4dip phosphodiesterase 4D interacting protein (myomegalin) [ Mus musculus (house mouse) ]

Gene ID: 83679, updated on 27-Nov-2024

Summary

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Official Symbol
Pde4dipprovided by MGI
Official Full Name
phosphodiesterase 4D interacting protein (myomegalin)provided by MGI
Primary source
MGI:MGI:1891434
See related
Ensembl:ENSMUSG00000038170 AllianceGenome:MGI:1891434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Usmg4; mKIAA0454; D3Bwg1078e; 4732458A06Rik; 9430063L05Rik; D130016K21Rik
Summary
Predicted to enable enzyme binding activity and molecular adaptor activity. Predicted to be involved in microtubule cytoskeleton organization; protein-containing complex assembly; and regulation of organelle organization. Predicted to be located in myofibril and nucleus. Predicted to be active in Golgi apparatus and centrosome. Predicted to colocalize with cortical microtubule plus-end. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PDE4DIP (phosphodiesterase 4D interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in heart adult (RPKM 75.3), mammary gland adult (RPKM 16.2) and 13 other tissues See more
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Genomic context

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See Pde4dip in Genome Data Viewer
Location:
3 F2.2; 3 42.28 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97597144..97796023, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (97689828..97888707, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9010 Neighboring gene STARR-positive B cell enhancer ABC_E6086 Neighboring gene protein kinase, AMP-activated, beta 2 non-catalytic subunit Neighboring gene nuclear encoded tRNA glutamine 2 (anticodon CTG) Neighboring gene predicted gene, 31242 Neighboring gene microRNA 7225 Neighboring gene predicted gene, 31305 Neighboring gene STARR-positive B cell enhancer ABC_E7930 Neighboring gene predicted gene, 46816 Neighboring gene transformer 2 alpha homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_08475 Neighboring gene STARR-positive B cell enhancer ABC_E4564 Neighboring gene SEC22 homolog B, vesicle trafficking protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:97732943-97733126 Neighboring gene STARR-positive B cell enhancer ABC_E3452 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:97737302-97737411 Neighboring gene VISTA enhancer mm576 Neighboring gene predicted gene 5544

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hemodynamic stress-induced cardiac remodelling is not modulated by ablation of phosphodiesterase 4D interacting protein. Mohamed BA, et al. J Cell Mol Med, 2022 Aug. PMID 35860864, Free PMC Article
  2. Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity. Keeney JG, et al. Mamm Genome, 2015 Feb. PMID 25308000, Free PMC Article
  3. Direct interaction of the Usher syndrome 1G protein SANS and myomegalin in the retina. Overlack N, et al. Biochim Biophys Acta, 2011 Oct. PMID 21767579
  4. Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. Verde I, et al. J Biol Chem, 2001 Apr 6. PMID 11134006
  5. Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice. Rouger K, et al. Am J Physiol Cell Physiol, 2002 Sep. PMID 12176734

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0477, MGC176146

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in astral microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
colocalizes_with cortical microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in myofibril ISO
Inferred from Sequence Orthology
more info
  
located_in myofibril ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
myomegalin
Names
phosphodiesterase 4D-interacting protein
upregulated during skeletal muscle growth 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039376.2 → NP_001034465.2  myomegalin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 5.
    Source sequence(s)
    AA727946, AC130541, AK122286, BB636676, BC028274, BC046620, BM950385, BQ042855, BQ554472, BU613416, BX517394, CB523595, CF532518, CO428791, CO432192, CR757260
    UniProtKB/TrEMBL
    B2RUJ9
    Conserved Domains (4) summary
    TIGR02168
    Location:123 → 770
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06758
    Location:1684 → 1745
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07851
    Location:362 → 457
    TMPIT; TMPIT-like protein
    pfam07989
    Location:126 → 193
    Cnn_1N; Centrosomin N-terminal motif 1

  2. NM_001289701.1 → NP_001276630.1  myomegalin isoform 5

    See identical proteins and their annotated locations for NP_001276630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AC130541, AC131746, AC153661
    Consensus CDS
    CCDS79985.1
    UniProtKB/TrEMBL
    B2RUJ9, G3X9L9
    Related
    ENSMUSP00000088254.6, ENSMUST00000090750.12
    Conserved Domains (4) summary
    TIGR02168
    Location:123 → 770
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06758
    Location:1684 → 1745
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07851
    Location:362 → 457
    TMPIT; TMPIT-like protein
    pfam07989
    Location:126 → 193
    Cnn_1N; Centrosomin N-terminal motif 1

  3. NM_001289702.1 → NP_001276631.1  myomegalin isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 5. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 5.
    Source sequence(s)
    AC130541, AC131746, AC153661
    Consensus CDS
    CCDS79984.1
    UniProtKB/TrEMBL
    B7ZNY0, E9Q1A0
    Related
    ENSMUSP00000131170.3, ENSMUST00000168438.9
    Conserved Domains (4) summary
    TIGR02168
    Location:123 → 770
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06758
    Location:1684 → 1745
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07851
    Location:362 → 457
    TMPIT; TMPIT-like protein
    pfam07989
    Location:126 → 193
    Cnn_1N; Centrosomin N-terminal motif 1

  4. NM_178080.4 → NP_835181.2  myomegalin isoform 2

    See identical proteins and their annotated locations for NP_835181.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the UTRs and coding region compared to variant 5. The resulting isoform (2) has much shorter and distinct N- and C-termini compared to isoform 5.
    Source sequence(s)
    BC050783, BU506330, CJ127389
    Consensus CDS
    CCDS38562.1
    UniProtKB/Swiss-Prot
    Q80YT7
    Related
    ENSMUSP00000040905.9, ENSMUST00000045243.15
    Conserved Domains (3) summary
    PRK02224
    Location:637 → 1116
    PRK02224; chromosome segregation protein; Provisional
    pfam07776
    Location:4 → 78
    zf-AD; Zinc-finger associated domain (zf-AD)
    pfam07851
    Location:405 → 500
    TMPIT; TMPIT-like protein

RNA

  1. NR_110360.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC153661, AK122286, BC057350, BP760882

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    97597144..97796023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001110163.1: Suppressed sequence

    Description
    NM_001110163.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_031401.2: Suppressed sequence

    Description
    NM_031401.2: This RefSeq was permanently suppressed because it comprises 3' UTR sequence and does not encode any part of the Pde4dip protein.

  3. NM_177145.3: Suppressed sequence

    Description
    NM_177145.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YT7.2 GenPept UniProtKB/Swiss-Prot:Q80YT7

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