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Tpbg trophoblast glycoprotein [ Rattus norvegicus (Norway rat) ]

Gene ID: 83684, updated on 27-Nov-2024

Summary

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Official Symbol
Tpbgprovided by RGD
Official Full Name
trophoblast glycoproteinprovided by RGD
Primary source
RGD:621453
See related
EnsemblRapid:ENSRNOG00000010694 AllianceGenome:RGD:621453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
5T4; WAIF1
Summary
Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including dendrite arborization; olfactory learning; and positive regulation of intracellular signal transduction. Predicted to be located in axon terminus; dendrite; and endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human TPBG (trophoblast glycoprotein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 45.8), Lung (RPKM 45.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tpbg in Genome Data Viewer
Location:
8q31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (95673993..95677364)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (86793953..86797324)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (93491761..93495132)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094219 Neighboring gene ribosomal protein L7 like 3 Neighboring gene uncharacterized LOC134480084 Neighboring gene ubiquitin protein ligase E3D Neighboring gene stathmin-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen. Shaw DM, et al. Biochem J, 2002 Apr 1. PMID 11903056, Free PMC Article
  2. Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Barrow KM, et al. Dev Dyn, 2005 Aug. PMID 15977177
  3. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Teckchandani A, et al. J Cell Biol, 2009 Jul 13. PMID 19581412, Free PMC Article
  4. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93332

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dendrite arborization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mesenchymal cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within olfactory learning ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
trophoblast glycoprotein
Names
5T4 oncofetal trophoblast glycoprotein
5T4 oncotrophoblast glycoprotein
wnt-activated inhibitory factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431631.1 → NP_001418560.1  trophoblast glycoprotein precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5PQV5, Q9QYD9
    UniProtKB/TrEMBL
    A6I1T6

  2. NM_031807.3 → NP_113995.2  trophoblast glycoprotein precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5PQV5, Q9QYD9
    UniProtKB/TrEMBL
    A6I1T6
    Conserved Domains (4) summary
    smart00013
    Location:62 → 95
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:300 → 351
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:73 → 95
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:91 → 154
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    95673993..95677364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243499.5 → XP_006243561.1  trophoblast glycoprotein isoform X1

    Related
    ENSRNOP00000099969.1, ENSRNOT00000153056.1
    Conserved Domains (4) summary
    smart00013
    Location:62 → 95
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:300 → 351
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:73 → 95
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:91 → 154
    LRR_8; Leucine rich repeat

  2. XM_017595935.3 → XP_017451424.1  trophoblast glycoprotein isoform X1

    UniProtKB/Swiss-Prot
    Q5PQV5, Q9QYD9
    UniProtKB/TrEMBL
    A6I1T6
    Related
    ENSRNOP00000100654.1, ENSRNOT00000139740.1
    Conserved Domains (4) summary
    smart00013
    Location:62 → 95
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:300 → 351
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:73 → 95
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:91 → 154
    LRR_8; Leucine rich repeat

  3. XM_008766457.4 → XP_008764679.1  trophoblast glycoprotein isoform X1

    See identical proteins and their annotated locations for XP_008764679.1

    UniProtKB/Swiss-Prot
    Q5PQV5, Q9QYD9
    UniProtKB/TrEMBL
    A6I1T6
    Related
    ENSRNOP00000101915.1, ENSRNOT00000130631.1
    Conserved Domains (4) summary
    smart00013
    Location:62 → 95
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:300 → 351
    LRRCT; Leucine rich repeat C-terminal domain
    sd00033
    Location:73 → 95
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:91 → 154
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQV5.1 GenPept UniProtKB/Swiss-Prot:Q5PQV5

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