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Srrt serrate RNA effector molecule homolog (Arabidopsis) [ Mus musculus (house mouse) ]

Gene ID: 83701, updated on 27-Nov-2024

Summary

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Official Symbol
Srrtprovided by MGI
Official Full Name
serrate RNA effector molecule homolog (Arabidopsis)provided by MGI
Primary source
MGI:MGI:1933527
See related
Ensembl:ENSMUSG00000037364 AllianceGenome:MGI:1933527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ars2; Asr2; ASR2A; ASR2B; ASR2C; ASR2D; 2810019G02Rik
Summary
Enables DNA binding activity. Involved in neuronal stem cell population maintenance; positive regulation of neurogenesis; and regulation of gene expression. Located in cytoplasm and nucleoplasm. Is expressed in several structures, including genitourinary system; liver; lung; retina; and spleen. Orthologous to human SRRT (serrate, RNA effector molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 42.3), thymus adult (RPKM 37.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Srrt in Genome Data Viewer
Location:
5 G2; 5 76.33 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137293966..137306564, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137295704..137307716, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acetylcholinesterase Neighboring gene microRNA 8116 Neighboring gene UFM1-specific peptidase 1 Neighboring gene microRNA 7036 Neighboring gene STARR-seq mESC enhancer starr_14639 Neighboring gene predicted gene 43013 Neighboring gene thyroid hormone receptor interactor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ARS2 is required for retinal progenitor cell S-phase progression and Müller glial cell fate specification. O'Sullivan C, et al. Biochem Cell Biol, 2020 Feb. PMID 30673303
  2. Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle Progression and MicroRNA and Replication-Dependent Histone mRNA Biogenesis. O'Sullivan C, et al. Mol Cell Biol, 2015 Nov. PMID 26303529, Free PMC Article
  3. ARS2 is a conserved eukaryotic gene essential for early mammalian development. Wilson MD, et al. Mol Cell Biol, 2008 Mar. PMID 18086880, Free PMC Article
  4. Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses. Olejniczak SH, et al. Proc Natl Acad Sci U S A, 2013 Jan 2. PMID 23248281, Free PMC Article
  5. Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Andreu-Agullo C, et al. Nature, 2011 Dec 25. PMID 22198669, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ars2 is an essential neural regulator that interacts dynamically with DNA and controls neural lineage development.
    Title: Regulation of embryonic and adult neurogenesis by Ars2.
  2. The Arsenic-resistance protein 2 (ARS2, also known as SRRT) is a component of the nuclear cap-binding complex involved in RNA Polymerase II transcription, and is required for cell cycle progression.
    Title: ARS2 is required for retinal progenitor cell S-phase progression and Müller glial cell fate specification.
  3. ARS2 plays a central role in RNA recognition and processing through multiple protein and RNA interactions.
    Title: Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle Progression and MicroRNA and Replication-Dependent Histone mRNA Biogenesis.
  4. findings reveal Ars2 as a new transcription factor that controls the multipotent progenitor state of NSCs through direct activation of the pluripotency factor Sox2
    Title: Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2.
  5. These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.
    Title: Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.
  6. These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process.
    Title: ARS2 is a conserved eukaryotic gene essential for early mammalian development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA cap binding complex binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA cap binding complex binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in primary miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in primary miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in primary miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serrate RNA effector molecule homolog
Names
arsenate resistance protein 2
arsenite-resistance protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109909.1 → NP_001103379.1  serrate RNA effector molecule homolog isoform 2

    See identical proteins and their annotated locations for NP_001103379.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different acceptor splice site at the penultimate exon compared to transcript variant 1, resulting in a shorter isoform (2) missing a 7 aa segment, compared to isoform 1.
    Source sequence(s)
    AA986426, BC066831, CJ175065
    Consensus CDS
    CCDS80440.1
    UniProtKB/Swiss-Prot
    Q99MR6
    Related
    ENSMUSP00000143232.2, ENSMUST00000199243.5
    Conserved Domains (2) summary
    pfam04959
    Location:645 → 843
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153 → 262
    DUF3546; Domain of unknown function (DUF3546)

  2. NM_001109910.1 → NP_001103380.1  serrate RNA effector molecule homolog isoform 3

    See identical proteins and their annotated locations for NP_001103380.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses different acceptor splice sites at the second and third to last exons compared to transcript variant 1, resulting in a shorter isoform (3) compared to isoform 1.
    Source sequence(s)
    AA986426, AK152710, BC066831, CJ175065
    Consensus CDS
    CCDS80439.1
    UniProtKB/Swiss-Prot
    Q99MR6
    Related
    ENSMUSP00000142564.2, ENSMUST00000197466.5
    Conserved Domains (2) summary
    pfam04959
    Location:645 → 839
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153 → 262
    DUF3546; Domain of unknown function (DUF3546)

  3. NM_001359602.1 → NP_001346531.1  serrate RNA effector molecule homolog isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC150682, AC243288
    Conserved Domains (2) summary
    pfam04959
    Location:645 → 846
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153 → 262
    DUF3546; Domain of unknown function (DUF3546)

  4. NM_031405.2 → NP_113582.1  serrate RNA effector molecule homolog isoform 1

    See identical proteins and their annotated locations for NP_113582.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA986426, BC066831, CB195376, CJ175065
    Consensus CDS
    CCDS39331.1
    UniProtKB/Swiss-Prot
    Q3UD04, Q5D042, Q8VEE6, Q99MR4, Q99MR5, Q99MR6, Q99MR7
    Conserved Domains (2) summary
    pfam04959
    Location:645 → 850
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:153 → 262
    DUF3546; Domain of unknown function (DUF3546)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137293966..137306564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254930.2 → XP_030110790.1  serrate RNA effector molecule homolog isoform X4

    Conserved Domains (2) summary
    pfam04959
    Location:418 → 612
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:1 → 35
    DUF3546; Domain of unknown function (DUF3546)

  2. XM_030254929.2 → XP_030110789.1  serrate RNA effector molecule homolog isoform X3

    Conserved Domains (2) summary
    pfam04959
    Location:418 → 623
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:1 → 35
    DUF3546; Domain of unknown function (DUF3546)

  3. XM_006504631.3 → XP_006504694.1  serrate RNA effector molecule homolog isoform X2

    Conserved Domains (2) summary
    pfam04959
    Location:480 → 685
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:32 → 97
    DUF3546; Domain of unknown function (DUF3546)

  4. XM_030254928.2 → XP_030110788.1  serrate RNA effector molecule homolog isoform X3

    Conserved Domains (2) summary
    pfam04959
    Location:418 → 623
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:1 → 35
    DUF3546; Domain of unknown function (DUF3546)

  5. XM_036165632.1 → XP_036021525.1  serrate RNA effector molecule homolog isoform X2

    Conserved Domains (2) summary
    pfam04959
    Location:480 → 685
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:32 → 97
    DUF3546; Domain of unknown function (DUF3546)

  6. XM_036165633.1 → XP_036021526.1  serrate RNA effector molecule homolog isoform X3

    Conserved Domains (2) summary
    pfam04959
    Location:418 → 623
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:1 → 35
    DUF3546; Domain of unknown function (DUF3546)

  7. XM_030254927.2 → XP_030110787.1  serrate RNA effector molecule homolog isoform X2

    Conserved Domains (2) summary
    pfam04959
    Location:480 → 685
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:32 → 97
    DUF3546; Domain of unknown function (DUF3546)

  8. XM_006504630.2 → XP_006504693.1  serrate RNA effector molecule homolog isoform X1

    See identical proteins and their annotated locations for XP_006504693.1

    Conserved Domains (2) summary
    pfam04959
    Location:548 → 753
    ARS2; Arsenite-resistance protein 2
    pfam12066
    Location:56 → 165
    DUF3546; Domain of unknown function (DUF3546)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MR6.1 GenPept UniProtKB/Swiss-Prot:Q99MR6

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