U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KCS3 3-ketoacyl-CoA synthase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837286, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
KCS3
Official Full Name
3-ketoacyl-CoA synthase 3
Primary source
TAIR:AT1G07720
Locus tag
AT1G07720
See related
Araport:AT1G07720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
3-ketoacyl-CoA synthase 3; F24B9.18; F24B9_18
Summary
Encodes KCS3, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See KCS3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
1
Sequence:
Chromosome: 1; NC_003070.9 (2390531..2392628, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene NOT2 / NOT3 / NOT5 family Neighboring gene ncRNA Neighboring gene Ankyrin repeat family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene exocyst subunit exo70 family protein H6

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An ancestral role for 3-KETOACYL-COA SYNTHASE3 as a negative regulator of plant cuticular wax synthesis. Huang H, et al. Plant Cell, 2023 May 29. PMID 36807983, Free PMC Article
  2. Fine-tuning the activities of β-KETOACYL-COA SYNTHASE 3 (KCS3) and KCS12 in Arabidopsis is essential for maintaining cuticle integrity. Huang H, et al. J Exp Bot, 2023 Nov 21. PMID 37615538
  3. Characterization of the closely related Arabidopsis thaliana β-ketoacyl-CoA synthases KCS3, KCS12 and KCS19. Zhang Z, et al. Plant J, 2024 Jul. PMID 38666591
  4. The VLCFA elongase gene family in Arabidopsis thaliana: phylogenetic analysis, 3D modelling and expression profiling. Joubès J, et al. Plant Mol Biol, 2008 Jul. PMID 18465198
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of the closely related Arabidopsis thaliana beta-ketoacyl-CoA synthases KCS3, KCS12 and KCS19.
    Title: Characterization of the closely related Arabidopsis thaliana β-ketoacyl-CoA synthases KCS3, KCS12 and KCS19.
  2. Fine-tuning the activities of beta-KETOACYL-COA SYNTHASE 3 (KCS3) and KCS12 in Arabidopsis is essential for maintaining cuticle integrity.
    Title: Fine-tuning the activities of β-KETOACYL-COA SYNTHASE 3 (KCS3) and KCS12 in Arabidopsis is essential for maintaining cuticle integrity.
  3. An ancestral role for 3-KETOACYL-COA SYNTHASE3 as a negative regulator of plant cuticular wax synthesis.
    Title: An ancestral role for 3-KETOACYL-COA SYNTHASE3 as a negative regulator of plant cuticular wax synthesis.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help
NM_100646.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables fatty acid elongase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
3-ketoacyl-CoA synthase 3
NP_172251.1
  • 3-ketoacyl-CoA synthase 3 (KCS3); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acyltransferase activity; INVOLVED IN: response to cold, response to light stimulus, response to osmotic stress; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase-like (InterPro:IPR016039), Very-long-chain 3-ketoacyl-CoA synthase (InterPro:IPR012392), 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal (InterPro:IPR013747), FAE1/Type III polyketide synthase-like protein (InterPro:IPR013601), Thiolase-like, subgroup (InterPro:IPR016038); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-CoA synthase 12 (TAIR:AT2G28630.1); Has 2897 Blast hits to 2863 proteins in 795 species: Archae - 0; Bacteria - 1421; Metazoa - 0; Fungi - 2; Plants - 1311; Viruses - 0; Other Eukaryotes - 163 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    2390531..2392628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001331724.1 → NP_001322003.1  3-ketoacyl-CoA synthase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AST0, A0A5S9T6V9, A0A7G2DR08

  2. NM_100646.3 → NP_172251.1  3-ketoacyl-CoA synthase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172251.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LQP8
    UniProtKB/TrEMBL
    A0A178W3A1, A0A5S9T6V9, A0A7G2DR08
    Conserved Domains (2) summary
    pfam08392
    Location:23 → 300
    FAE1_CUT1_RppA; FAE1/Type III polyketide synthase-like protein
    cl21486
    Location:334 → 424
    Ketoacyl-synt_C; Beta-ketoacyl synthase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LQP8.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.