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MOM ATP-dependent helicase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837322, updated on 18-Sep-2024

Summary

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Official Symbol
MOM
Official Full Name
ATP-dependent helicase family protein
Primary source
TAIR:AT1G08060
Locus tag
AT1G08060
See related
Araport:AT1G08060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MAINTENANCE OF METHYLATION; MOM1; MORPHEUS MOLECULE; MORPHEUS MOLECULE 1; T6D22.14; T6D22_14
Summary
Encodes a transcriptional silencer.
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Genomic context

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See MOM in Genome Data Viewer
Location:
chromosome: 1
Exon count:
16
Sequence:
Chromosome: 1; NC_003070.9 (2501704..2511084, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene trimethylguanosine synthase (DUF707) Neighboring gene Zinc finger (C3HC4-type RING finger) family protein Neighboring gene alpha carbonic anhydrase 5 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1. Nishimura T, et al. PLoS Genet, 2012 Feb. PMID 22346760, Free PMC Article
  2. Disruption of the plant gene MOM releases transcriptional silencing of methylated genes. Amedeo P, et al. Nature, 2000 May 11. PMID 10821279
  3. Divergent evolution of CHD3 proteins resulted in MOM1 refining epigenetic control in vascular plants. Caikovski M, et al. PLoS Genet, 2008 Aug 22. PMID 18725928, Free PMC Article
  4. MOM1 and Pol-IV/V interactions regulate the intensity and specificity of transcriptional gene silencing. Yokthongwattana C, et al. EMBO J, 2010 Jan 20. PMID 19910926, Free PMC Article
  5. Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein. Petty TJ, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Aug 1. PMID 20693667, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Canonical transcriptional gene silencing may contribute to long-term heat response and recovery through MOM1.
    Title: Canonical transcriptional gene silencing may contribute to long-term heat response and recovery through MOM1.
  2. The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.
    Title: The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation.
  3. The SUMO interaction motif responsible for the interaction of MOM1 with SUMO.
    Title: Exploring potential roles for the interaction of MOM1 with SUMO and the SUMO E3 ligase-like protein PIAL2 in transcriptional silencing.
  4. study suggests that PIAL1 and PIAl2 act as components of the MOM1-containing complex to mediate transcriptional silencing at heterochromatin regions.
    Title: The SUMO E3 Ligase-Like Proteins PIAL1 and PIAL2 Interact with MOM1 and Form a Novel Complex Required for Transcriptional Silencing.
  5. Data indicate function of DNA methylation1 (DDM1) and Morpheus' Molecule1 (MOM1) in rapid resetting of stress induced epigenetic states, and therefore also in preventing their mitotic propagation and transgenerational inheritance.
    Title: Identification of genes preventing transgenerational transmission of stress-induced epigenetic states.
  6. synergistic transcriptional regulation in the mom1/atmorc6 double mutant, indicating that these epigenetic regulators act mainly in different silencing pathways, both independently of DNA methylation
    Title: Transcriptional gene silencing by Arabidopsis microrchidia homologues involves the formation of heteromers.
  7. These results reveal a surprising separation of epigenetic activities that enable the single, large MOM1 protein to coordinate cooperating mechanisms of epigenetic regulation
    Title: Structural basis of transcriptional gene silencing mediated by Arabidopsis MOM1.
  8. the degree of contribution of MOM1 to maintenance of the silent states varies in different loci, and other silencing machineries, including those in the RNA-directed DNA methylation pathway, interact genetically with MOM1
    Title: Epigenetic silencing of endogenous repetitive sequences by MORPHEUS' MOLECULE1 in Arabidopsis thaliana.
  9. MOM1 plays a role in preventing aberrant RNA transcriptional read-through.
    Title: MORPHEUS' MOLECULE1 is required to prevent aberrant RNA transcriptional read-through in Arabidopsis.
  10. Crystals of Morpheus' molecule 1 belonged to the trigonal space group P3(1)21 (or P3(2)21), with unit-cell parameters a=85.64, c=292.74 A. Structure determination is ongoing
    Title: Expression, crystallization and preliminary X-ray diffraction analysis of the CMM2 region of the Arabidopsis thaliana Morpheus' molecule 1 protein.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001331755.1
NM_100680.4
NM_179277.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables SUMO binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene silencing by regulatory ncRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
ATP-dependent helicase family protein
NP_563806.1
  • MORPHEUS MOLECULE (MOM); INVOLVED IN: chromatin silencing; LOCATED IN: nucleus; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 7 growth stages; BEST Arabidopsis thaliana protein match is: chromatin remodeling 4 (TAIR:AT5G44800.1); Has 8505 Blast hits to 7857 proteins in 726 species: Archae - 6; Bacteria - 999; Metazoa - 3217; Fungi - 2019; Plants - 785; Viruses - 95; Other Eukaryotes - 1384 (source: NCBI BLink).
NP_849608.1
  • MORPHEUS MOLECULE (MOM); INVOLVED IN: chromatin silencing; LOCATED IN: nucleus; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 7 growth stages; BEST Arabidopsis thaliana protein match is: chromatin remodeling 4 (TAIR:AT5G44800.1); Has 8505 Blast hits to 7857 proteins in 726 species: Archae - 6; Bacteria - 999; Metazoa - 3217; Fungi - 2019; Plants - 785; Viruses - 95; Other Eukaryotes - 1384 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    2501704..2511084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100680.4 → NP_563806.1  ATP-dependent helicase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563806.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GXZ0, Q9LN02, Q9M658, Q9M659
    UniProtKB/TrEMBL
    A0A5S9T7U8
    Conserved Domains (1) summary
    pfam06752
    Location:1830 → 1993
    E_Pc_C; Enhancer of Polycomb C-terminus

  2. NM_001331755.1 → NP_001322007.1  ATP-dependent helicase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ASM1, A0A5S9T7U8

  3. NM_179277.1 → NP_849608.1  ATP-dependent helicase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849608.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8GXZ0, Q9LN02, Q9M658, Q9M659
    UniProtKB/TrEMBL
    A0A5S9T7U8
    Conserved Domains (1) summary
    pfam06752
    Location:1830 → 1993
    E_Pc_C; Enhancer of Polycomb C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9M658.1

Gene LinkOut

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