THA1 threonine aldolase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: THA1
Official Full Name: threonine aldolase 1
Primary source: TAIR:AT1G08630
Locus tag: AT1G08630
See related: Araport:AT1G08630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F22O13.11; F22O13_11; threonine aldolase 1
Summary: Encodes a threonine aldolase, involved in threonine degradation to glycine. Primarily expressed in seeds and seedlings.
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Genomic context

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See THA1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 11

Sequence:: Chromosome: 1; NC_003070.9 (2743761..2747967, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Seed-specific expression of feedback-insensitive Thr deaminase in both tha1 and tha2 Thr aldolase mutants greatly increases seed Ile content, suggesting that these two Thr catabolic enzymes compete for a common substrate pool.[THA1]
Title: Two Arabidopsis threonine aldolases are nonredundant and compete with threonine deaminase for a common substrate pool.

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Pathways from PubChem

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General gene information

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NM_001035924.2

Supported by ESTs:

NM_001084023.1

Supported by ESTs:

NM_001331780.1

Supported by ESTs:

NM_001331781.1

Supported by ESTs:

NM_100736.3

Supported by ESTs:

NM_179283.2

Supported by ESTs:

NM_179284.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables threonine aldolase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within threonine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: threonine aldolase 1

NP_001077492.1

threonine aldolase 1 (THA1); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aromatic amino acid beta-eliminating lyase/threonine aldolase (InterPro:IPR001597), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: threonine aldolase 2 (TAIR:AT3G04520.2); Has 3797 Blast hits to 3793 proteins in 1149 species: Archae - 25; Bacteria - 2286; Metazoa - 91; Fungi - 253; Plants - 87; Viruses - 0; Other Eukaryotes - 1055 (source: NCBI BLink).

NP_001318956.1

threonine aldolase 1 (THA1); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aromatic amino acid beta-eliminating lyase/threonine aldolase (InterPro:IPR001597), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: threonine aldolase 2 (TAIR:AT3G04520.1); Has 4107 Blast hits to 4101 proteins in 1235 species: Archae - 29; Bacteria - 2521; Metazoa - 93; Fungi - 250; Plants - 87; Viruses - 0; Other Eukaryotes - 1127 (source: NCBI BLink).

NP_563822.1

threonine aldolase 1 (THA1); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aromatic amino acid beta-eliminating lyase/threonine aldolase (InterPro:IPR001597), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: threonine aldolase 2 (TAIR:AT3G04520.1); Has 4107 Blast hits to 4101 proteins in 1235 species: Archae - 29; Bacteria - 2521; Metazoa - 93; Fungi - 250; Plants - 87; Viruses - 0; Other Eukaryotes - 1127 (source: NCBI BLink).

NP_849614.1

threonine aldolase 1 (THA1); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aromatic amino acid beta-eliminating lyase/threonine aldolase (InterPro:IPR001597), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: threonine aldolase 2 (TAIR:AT3G04520.1); Has 4107 Blast hits to 4101 proteins in 1235 species: Archae - 29; Bacteria - 2521; Metazoa - 93; Fungi - 250; Plants - 87; Viruses - 0; Other Eukaryotes - 1127 (source: NCBI BLink).

NP_849615.1

threonine aldolase 1 (THA1); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aromatic amino acid beta-eliminating lyase/threonine aldolase (InterPro:IPR001597), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: threonine aldolase 2 (TAIR:AT3G04520.1); Has 4107 Blast hits to 4101 proteins in 1235 species: Archae - 29; Bacteria - 2521; Metazoa - 93; Fungi - 250; Plants - 87; Viruses - 0; Other Eukaryotes - 1127 (source: NCBI BLink).