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TAS1R3 taste 1 receptor member 3 [ Homo sapiens (human) ]

Gene ID: 83756, updated on 27-Nov-2024

Summary

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Official Symbol
TAS1R3provided by HGNC
Official Full Name
taste 1 receptor member 3provided by HGNC
Primary source
HGNC:HGNC:15661
See related
Ensembl:ENSG00000169962 MIM:605865; AllianceGenome:HGNC:15661
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T1R3
Summary
The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]
Expression
Broad expression in salivary gland (RPKM 1.8), duodenum (RPKM 0.7) and 22 other tissues See more
Orthologs
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Genomic context

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See TAS1R3 in Genome Data Viewer
Location:
1p36.33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1331280..1335314)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (762865..766905)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1266660..1270694)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 11 Neighboring gene microRNA 6727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1253662-1254352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1254353-1255043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1257229-1257737 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1258501-1259010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 59 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 60 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 61 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene microRNA 6808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1281421-1282299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1282501-1283130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1283131-1283760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 62 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 64 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1288877-1289508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1289509-1290140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1290141-1290771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1291896-1292448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1293036-1293618 Neighboring gene matrix remodeling associated 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 65

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Five amino acid residues in cysteine-rich domain of human T1R3 were involved in the response for sweet-tasting protein, thaumatin. Masuda T, et al. Biochimie, 2013 Jul. PMID 23370115
  2. Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer. Tsutsumi R, et al. Laryngoscope, 2016 Mar. PMID 26422579
  3. Rubemamine and Rubescenamine, Two Naturally Occurring N-Cinnamoyl Phenethylamines with Umami-Taste-Modulating Properties. Backes M, et al. J Agric Food Chem, 2015 Oct 7. PMID 26375852
  4. Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. Fushan AA, et al. Curr Biol, 2009 Aug 11. PMID 19559618, Free PMC Article
  5. Activation of the sweet taste receptor T1R3 by sucralose attenuates VEGF-induced vasculogenesis in a cell model of the retinal microvascular endothelium. Lizunkova P, et al. Graefes Arch Clin Exp Ophthalmol, 2019 Jan. PMID 30353220, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heterodimerization of Chemoreceptors TAS1R3 and mGlu2 in Human Blood Leukocytes.
    Title: Heterodimerization of Chemoreceptors TAS1R3 and mGlu(2) in Human Blood Leukocytes.
  2. Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.
    Title: Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3.
  3. TAS1R3 and TAS2R38 Polymorphisms Affect Sweet Taste Perception: An Observational Study on Healthy and Obese Subjects.
    Title: TAS1R3 and TAS2R38 Polymorphisms Affect Sweet Taste Perception: An Observational Study on Healthy and Obese Subjects.
  4. Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
    Title: Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
  5. Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
    Title: Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
  6. Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3.
    Title: Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3.
  7. Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
    Title: Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
  8. Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor.
    Title: Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor.
  9. Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
    Title: Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
  10. Using homology modeling, molecular docking and molecular dynamics (MD) simulations, this study investigates the effects of five natural umami ligands on the structural dynamics of T1R1-T1R3.
    Title: Understanding the molecular mechanism of umami recognition by T1R1-T1R3 using molecular dynamics simulations.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to sweet taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to sweet taste receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to taste receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables taste receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of sweet taste IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sensory perception of sweet taste IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sweet taste IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sensory perception of umami taste IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of umami taste IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in membrane IC
Inferred by Curator
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of sweet taste receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
taste receptor type 1 member 3
Names
sweet taste receptor T1R3
taste receptor, type 1, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152228.3 → NP_689414.2  taste receptor type 1 member 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL139287
    Consensus CDS
    CCDS30556.1
    UniProtKB/Swiss-Prot
    Q5TA49, Q7RTX0, Q8NGW9
    Related
    ENSP00000344411.5, ENST00000339381.6
    Conserved Domains (3) summary
    cd06363
    Location:29 → 488
    PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
    pfam07562
    Location:496 → 547
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15290
    Location:590 → 819
    7tmC_TAS1R3; type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1331280..1335314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002435.2 → XP_016857924.1  taste receptor type 1 member 3 isoform X1

  2. XM_017002436.2 → XP_016857925.1  taste receptor type 1 member 3 isoform X2

  3. XM_047431571.1 → XP_047287527.1  taste receptor type 1 member 3 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    762865..766905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338994.1 → XP_054194969.1  taste receptor type 1 member 3 isoform X1

  2. XM_054338995.1 → XP_054194970.1  taste receptor type 1 member 3 isoform X2

  3. XM_054338996.1 → XP_054194971.1  taste receptor type 1 member 3 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7RTX0.2 GenPept UniProtKB/Swiss-Prot:Q7RTX0

Gene LinkOut

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