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Pol{lambda} DNA polymerase lambda (POLL) [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837592, updated on 18-Sep-2024

Summary

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Official Symbol
Pol{lambda}
Official Full Name
DNA polymerase lambda (POLL)
Primary source
TAIR:AT1G10520
Locus tag
AT1G10520
See related
Araport:AT1G10520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtPol{lambda}; DNA polymerase {lambda}; T10O24.13; T10O24_13
Summary
Encodes a homolog of the mammalian DNA polymerase lambda that is involved in the repair of UV-B induced DNA damage.
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Genomic context

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See Pol{lambda} in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Sequence:
Chromosome: 1; NC_003070.9 (3465926..3469455)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene GNAT acetyltransferase (DUF699) Neighboring gene chloroplast-localized ISCA-like protein Neighboring gene RNI-like superfamily protein Neighboring gene ncRNA Neighboring gene Serine/Threonine-kinase Neighboring gene D-ribose-binding periplasmic protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The enzymatic properties of Arabidopsis thaliana DNA polymerase λ suggest a role in base excision repair. Morales-Ruiz T, et al. Plant Mol Biol, 2024 Jan 13. PMID 38217735, Free PMC Article
  2. Functional analysis of light-regulated promoter region of AtPolλ gene. Roy S, et al. Planta, 2012 Feb. PMID 21947619
  3. Understanding the Physical and Molecular Basis of Stability of Arabidopsis DNA Pol λ under UV-B and High NaCl Stress. Roy S, et al. PLoS One, 2015. PMID 26230318, Free PMC Article
  4. Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2. Amoroso A, et al. Plant Cell, 2011 Feb. PMID 21325140, Free PMC Article
  5. AtPolλ, a homolog of mammalian DNA polymerase λ in Arabidopsis thaliana, is involved in the repair of UV-B induced DNA damage through the dark repair pathway. Roy S, et al. Plant Cell Physiol, 2011 Feb. PMID 21227935

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The enzymatic properties of Arabidopsis thaliana DNA polymerase lambda suggest a role in base excision repair.
    Title: The enzymatic properties of Arabidopsis thaliana DNA polymerase λ suggest a role in base excision repair.
  2. A direct involvement of T1G10520 in the repair of the DNA double strand breaks in a plant genome.
    Title: Involvement of AtPolλ in the repair of high salt- and DNA cross-linking agent-induced double strand breaks in Arabidopsis.
  3. White light positively regulates AtPollambda expression.
    Title: Functional analysis of light-regulated promoter region of AtPolλ gene.
  4. DNA Pol lambda recognizes 8-Oxo-G on a template as a normal guanine and preferentially incorporates dCTP over dATP opposite this lesion.
    Title: Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_100926.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in base-excision repair, gap-filling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to UV-B IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
DNA polymerase lambda (POLL)
NP_172522.2
  • DNA polymerase lambda (POLL); FUNCTIONS IN: DNA binding, DNA-directed DNA polymerase activity, catalytic activity, nucleotidyltransferase activity; INVOLVED IN: DNA repair, DNA replication; LOCATED IN: intracellular; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: Nucleotidyl transferase domain (InterPro:IPR002934), DNA-directed DNA polymerase, family X, beta-like (InterPro:IPR002008), DNA-directed DNA polymerase, family X, beta-like, N-terminal (InterPro:IPR010996), DNA polymerase lambda, fingers domain (InterPro:IPR018944), DNA polymerase family X, binding site (InterPro:IPR019843), DNA-directed DNA polymerase X (InterPro:IPR002054), BRCT (InterPro:IPR001357), DNA polymerase X (InterPro:IPR022312); Has 1887 Blast hits to 1879 proteins in 557 species: Archae - 50; Bacteria - 688; Metazoa - 533; Fungi - 209; Plants - 50; Viruses - 7; Other Eukaryotes - 350 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    3465926..3469455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001331911.1 → NP_001320966.1  DNA polymerase lambda (POLL) [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W5U8, A0A1P8APE6

  2. NM_100926.3 → NP_172522.2  DNA polymerase lambda (POLL) [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172522.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FNY4, Q9XIK1
    UniProtKB/TrEMBL
    A0A178W586, A0A5S9TP53, A0A654E9R3
    Conserved Domains (2) summary
    cd00141
    Location:202 → 527
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    cl00038
    Location:21 → 63
    BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FNY4.1

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