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APA1 aspartic proteinase A1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837740, updated on 18-Sep-2024

Summary

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Official Symbol
APA1
Official Full Name
aspartic proteinase A1
Primary source
TAIR:AT1G11910
Locus tag
AT1G11910
See related
Araport:AT1G11910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
aspartic proteinase A1; ATAPA1; F12F1.24; F12F1_24
Summary
Encodes an aspartic proteinase that forms a heterodimer and is stable over a broad pH range (ph 3-8).
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Genomic context

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See APA1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
15
Sequence:
Chromosome: 1; NC_003070.9 (4016712..4021043, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene B-cell receptor-associated protein 31-like protein Neighboring gene wall-associated receptor kinase galacturonan-binding protein Neighboring gene Pectin lyase-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of Arabidopsis aspartic protease APA1 gene confers drought tolerance. Sebastián D, et al. Plant Sci, 2020 Mar. PMID 32005402
  2. Structure-function characterization of the recombinant aspartic proteinase A1 from Arabidopsis thaliana. Mazorra-Manzano MA, et al. Phytochemistry, 2010 Apr. PMID 20079503
  3. Expression and characterization of the recombinant aspartic proteinase A1 from Arabidopsis thaliana. Mazorra-Manzano MA, et al. Phytochemistry, 2008 Oct. PMID 18796341
  4. A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins. Hackbusch J, et al. Proc Natl Acad Sci U S A, 2005 Mar 29. PMID 15781858, Free PMC Article
  5. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_101062.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region HDA PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole HDA PubMed 
located_in plasmodesma HDA PubMed 
located_in secretory vesicle HDA PubMed 
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
aspartic proteinase A1
NP_172655.1
  • aspartic proteinase A1 (APA1); FUNCTIONS IN: endopeptidase activity; INVOLVED IN: proteolysis, response to salt stress; LOCATED IN: vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Saposin-like (InterPro:IPR011001), Peptidase aspartic (InterPro:IPR021109), Peptidase aspartic, catalytic (InterPro:IPR009007), Saposin-like type B, 1 (InterPro:IPR007856), Saposin-like type B, 2 (InterPro:IPR008138), Saposin B (InterPro:IPR008139), Peptidase A1 (InterPro:IPR001461), Peptidase aspartic, active site (InterPro:IPR001969); BEST Arabidopsis thaliana protein match is: Saposin-like aspartyl protease family protein (TAIR:AT1G62290.2); Has 7443 Blast hits to 5200 proteins in 420 species: Archae - 0; Bacteria - 2; Metazoa - 4134; Fungi - 1703; Plants - 675; Viruses - 0; Other Eukaryotes - 929 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    4016712..4021043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001332010.1 → NP_001322792.1  aspartic proteinase A1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AV08, A0A5S9TY91, A0A654EA66

  2. NM_101062.4 → NP_172655.1  aspartic proteinase A1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172655.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65390, Q38934
    UniProtKB/TrEMBL
    A0A178WAW2, A0A5S9TY91, A0A654EA66
    Conserved Domains (3) summary
    cd06098
    Location:72 → 504
    phytepsin; Phytepsin, a plant homolog of mammalian lysosomal pepsins
    pfam03489
    Location:315 → 348
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:380 → 415
    SapB_1; Saposin-like type B, region 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O65390.1

Gene LinkOut

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