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cry3b cryptochrome circadian regulator 3b [ Danio rerio (zebrafish) ]

Gene ID: 83780, updated on 4-Jan-2025

Summary

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Official Symbol
cry3bprovided by ZNC
Official Full Name
cryptochrome circadian regulator 3bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010426-5
See related
Ensembl:ENSDARG00000091131 AllianceGenome:ZFIN:ZDB-GENE-010426-5
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cry2b; cry1bb; zcry2b
Summary
Acts upstream of or within negative regulation of DNA-templated transcription. Is expressed in several structures, including brain; endocrine system; eye; intestine; and liver and biliary system. Human ortholog(s) of this gene implicated in delayed sleep phase syndrome. Orthologous to human CRY1 (cryptochrome circadian regulator 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See cry3b in Genome Data Viewer
Location:
chromosome: 22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (786543..808901)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (747802..792003)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 76 Neighboring gene retinoblastoma binding protein 5 Neighboring gene zgc:153675 Neighboring gene cryptochrome circadian regulator 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish CRY represses transcription mediated by CLOCK-BMAL heterodimer without inhibiting its binding to DNA. Ishikawa T, et al. Genes Cells, 2002 Oct. PMID 12354100
  2. Midnight/midday-synchronized expression of cryptochrome genes in the eyes of three teleost species, zebrafish, goldfish, and medaka. Nakagawa M, et al. Zoological Lett, 2022 Jun 7. PMID 35672786, Free PMC Article
  3. A photoperiodic time measurement served by the biphasic expression of Cryptochrome1ab in the zebrafish eye. Okano K, et al. Sci Rep, 2020 Mar 19. PMID 32193419, Free PMC Article
  4. Molecular analysis of zebrafish photolyase/cryptochrome family: two types of cryptochromes present in zebrafish. Kobayashi Y, et al. Genes Cells, 2000 Sep. PMID 10971654
  5. Single-cell in vivo imaging of cellular circadian oscillators in zebrafish. Wang H, et al. PLoS Biol, 2020 Mar. PMID 32168317, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cryptochrome circadian regulator 3b
Names
cryptochrome 2b
cryptochrome circadian clock 1bb
cryptochrome circadian regulator 1bb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131792.2 → NP_571867.2  cryptochrome circadian regulator 3b

    Status: VALIDATED

    Source sequence(s)
    CF995949, DT066237, EH497225, EH523517, EH530941, FP085425
    UniProtKB/TrEMBL
    A0A8M1PCZ5
    Related
    ENSDARP00000108036.2, ENSDART00000125347.3
    Conserved Domains (3) summary
    COG0415
    Location:5 → 494
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam00875
    Location:5 → 166
    DNA_photolyase; DNA photolyase
    pfam03441
    Location:213 → 489
    FAD_binding_7; FAD binding domain of DNA photolyase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    786543..808901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009295768.3 → XP_009294043.2  cryptochrome circadian regulator 3b isoform X1

    UniProtKB/TrEMBL
    A0A8M3AXA7
    Conserved Domains (2) summary
    pfam03441
    Location:293 → 489
    FAD_binding_7; FAD binding domain of DNA photolyase
    cl27275
    Location:5 → 494
    DNA_photolyase; DNA photolyase

  2. XM_021469382.2 → XP_021325057.1  cryptochrome circadian regulator 3b isoform X2

    UniProtKB/TrEMBL
    A0A8M9P4C5
    Related
    ENSDARP00000150344.1, ENSDART00000180188.1
    Conserved Domains (2) summary
    pfam03441
    Location:293 → 489
    FAD_binding_7; FAD binding domain of DNA photolyase
    cl27275
    Location:5 → 494
    DNA_photolyase; DNA photolyase

  3. XM_068216376.1 → XP_068072477.1  cryptochrome circadian regulator 3b isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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