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LPLAT1 MBOAT (membrane bound O-acyl transferase) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 837820, updated on 18-Sep-2024

Summary

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Official Symbol
LPLAT1
Official Full Name
MBOAT (membrane bound O-acyl transferase) family protein
Primary source
TAIR:AT1G12640
Locus tag
AT1G12640
See related
Araport:AT1G12640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtLPLAT1; LPCAT1; lysophosphatidylcholine acyltransferase 1; lysophospholipid acyltransferase 1; T12C24.17; T12C24_17
Summary
Encodes a lysophosphatidylcholine acyltransferase (LPCAT). Participates in the Lands cycle in developing seeds.
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Genomic context

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See LPLAT1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Sequence:
Chromosome: 1; NC_003070.9 (4303280..4305907, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene rRNA biogenesis RRP36-like protein Neighboring gene thionin-like protein Neighboring gene thionin-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LPCAT1 controls phosphate homeostasis in a zinc-dependent manner. Kisko M, et al. Elife, 2018 Feb 17. PMID 29453864, Free PMC Article
  2. Plant acyl-CoA:lysophosphatidylcholine acyltransferases (LPCATs) have different specificities in their forward and reverse reactions. Lager I, et al. J Biol Chem, 2013 Dec 27. PMID 24189065, Free PMC Article
  3. Castor LPCAT and PDAT1A Act in Concert to Promote Transacylation of Hydroxy-Fatty Acid onto Triacylglycerol. Lunn D, et al. Plant Physiol, 2020 Oct. PMID 32737074, Free PMC Article
  4. Metabolic interactions between the Lands cycle and the Kennedy pathway of glycerolipid synthesis in Arabidopsis developing seeds. Wang L, et al. Plant Cell, 2012 Nov. PMID 23150634, Free PMC Article
  5. Acyl editing and headgroup exchange are the major mechanisms that direct polyunsaturated fatty acid flux into triacylglycerols. Bates PD, et al. Plant Physiol, 2012 Nov. PMID 22932756, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Castor LPCAT and PDAT1A Act in Concert to Promote Transacylation of Hydroxy-Fatty Acid onto Triacylglycerol.
    Title: Castor LPCAT and PDAT1A Act in Concert to Promote Transacylation of Hydroxy-Fatty Acid onto Triacylglycerol.
  2. Using genome-wide association studies, the authors first identified allelic variation of the Lyso-PhosphatidylCholine (PC) AcylTransferase 1 (LPCAT1) gene as the key determinant of shoot inorganic phosphate accumulation under zinc deficiency.
    Title: LPCAT1 controls phosphate homeostasis in a zinc-dependent manner.
  3. LPCAT1 and LPCAT2 enzymes catalyzed the acylation and de-acylation of both sn positions of PC, with a preference for the sn-2 position.
    Title: Plant acyl-CoA:lysophosphatidylcholine acyltransferases (LPCATs) have different specificities in their forward and reverse reactions.
  4. Arabidopsis thaliana LPCATs, LPCAT1 and LPCAT2, participate in the Lands cycle in developing seeds.
    Title: Metabolic interactions between the Lands cycle and the Kennedy pathway of glycerolipid synthesis in Arabidopsis developing seeds.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_101134.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophospholipid acyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within galactolipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within glycerolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phospholipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within triglyceride biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
MBOAT (membrane bound O-acyl transferase) family protein
NP_172724.2
  • MBOAT (membrane bound O-acyl transferase) family protein; FUNCTIONS IN: acyltransferase activity; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Membrane bound O-acyl transferase, MBOAT (InterPro:IPR004299); BEST Arabidopsis thaliana protein match is: MBOAT (membrane bound O-acyl transferase) family protein (TAIR:AT1G63050.1); Has 1204 Blast hits to 1199 proteins in 313 species: Archae - 0; Bacteria - 269; Metazoa - 625; Fungi - 142; Plants - 47; Viruses - 0; Other Eukaryotes - 121 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    4303280..4305907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101134.5 → NP_172724.2  MBOAT (membrane bound O-acyl transferase) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172724.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IDU4, Q8RWH4, Q9LN83
    UniProtKB/TrEMBL
    A0A7G2DWC0
    Conserved Domains (1) summary
    PLN02332
    Location:1 → 462
    PLN02332; membrane bound O-acyl transferase (MBOAT) family protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4IDU4.1

Gene LinkOut

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