Agxt2 alanine-glyoxylate aminotransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Agxt2provided by RGD
Official Full Name: alanine-glyoxylate aminotransferase 2provided by RGD
Primary source: RGD:621767
See related: EnsemblRapid:ENSRNOG00000017821 AllianceGenome:RGD:621767
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AGT2
Summary: Enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity; alanine-glyoxylate transaminase activity; and beta-alanine:pyruvate transaminase activity. Involved in N(omega),N(omega)-dimethyl-L-arginine catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation; cerebral infarction; congestive heart failure; and mild cognitive impairment. Orthologous to human AGXT2 (alanine--glyoxylate aminotransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 3234.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (61063416..61104828)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (59336252..59377664)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (60337667..60379144)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA.
Title: Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA.
Our results suggest that D-AIB AT is distributed in the examined- just the regions and may play an important role there.
Title: Distribution of D-3-aminoisobutyrate-pyruvate aminotransferase in the rat brain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity	ISO Inferred from Sequence Orthology more info
enables alanine-glyoxylate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alanine-glyoxylate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables alanine-glyoxylate transaminase activity	ISO Inferred from Sequence Orthology more info
enables alanine-glyoxylate transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables beta-alanine:pyruvate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-alanine:pyruvate transaminase activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alanine catabolic process, by transamination	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-alanine catabolic process, by transamination	ISO Inferred from Sequence Orthology more info
involved_in N(omega),N(omega)-dimethyl-L-arginine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycine biosynthetic process, by transamination of glyoxylate	ISO Inferred from Sequence Orthology more info
involved_in glyoxylate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyoxylate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	TAS Traceable Author Statement more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: alanine--glyoxylate aminotransferase 2, mitochondrial

Names: (R)-3-amino-2-methylpropionate--pyruvate transaminase; AGT 2; D-3-aminoisobutyrate-pyruvate aminotransferase; D-AIBAT; D-beta-aminoisobutyrate-pyruvate aminotransferase; beta-ALAAT II; beta-alanine-pyruvate aminotransferase

NP_114023.1

EC 2.6.1.18

EC 2.6.1.40

EC 2.6.1.44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031835.2 → NP_114023.1 alanine--glyoxylate aminotransferase 2, mitochondrial

See identical proteins and their annotated locations for NP_114023.1

Status: PROVISIONAL

Source sequence(s)

BC081765

UniProtKB/Swiss-Prot

O08616, Q642F1, Q64565

UniProtKB/TrEMBL

A6KJT6, A6KJT7

Related

ENSRNOP00000024035.5, ENSRNOT00000024035.9

Conserved Domains (2) summary

cd00610
Location:65 → 503

OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...

TIGR00707
Location:79 → 503

argD; transaminase, acetylornithine/succinylornithine family