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NHX8 Na+/H+ exchanger 8 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838028, updated on 18-Sep-2024

Summary

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Official Symbol
NHX8
Official Full Name
Na+/H+ exchanger 8
Primary source
TAIR:AT1G14660
Locus tag
AT1G14660
See related
Araport:AT1G14660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATNHX8; F10B6.1; F10B6_1; Na+/H+ exchanger 8; SODIUM HYDROGEN EXCHANGER 8
Summary
member of putative Na+/H+ antiporter (AtNHX) family. Functions as a plasma membrane Li+/H+ antiporter. Involved in Li+ efflux and detoxification.
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Genomic context

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See NHX8 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
19
Sequence:
Chromosome: 1; NC_003070.9 (5031943..5036610, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SWAP (Suppressor-of-White-APricot)/surp domain-containing protein / ubiquitin family protein Neighboring gene ncRNA Neighboring gene Endomembrane protein 70 protein family Neighboring gene early endosome antigen

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AtNHX8, a member of the monovalent cation: proton antiporter-1 family in Arabidopsis thaliana, encodes a putative Li/H antiporter. An R, et al. Plant J, 2007 Feb. PMID 17270011
  2. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
  3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001198066.1
NM_101333.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables lithium:proton antiporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
NOT enables sodium ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lithium ion export across the plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lithium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in sodium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Na+/H+ exchanger 8
NP_001184995.1
  • Na+/H+ exchanger 8 (NHX8); CONTAINS InterPro DOMAIN/s: Cation/H+ exchanger, conserved region (InterPro:IPR018422), Cation/H+ exchanger (InterPro:IPR006153), Na+/H+ exchanger, isoforms 7/8, conserved region (InterPro:IPR018418); BEST Arabidopsis thaliana protein match is: sodium proton exchanger, putative (NHX7) (SOS1) (TAIR:AT2G01980.1).
NP_172918.2
  • Na+/H+ exchanger 8 (NHX8); CONTAINS InterPro DOMAIN/s: Cation/H+ exchanger, conserved region (InterPro:IPR018422), Cation/H+ exchanger (InterPro:IPR006153), Na+/H+ exchanger, isoforms 7/8, conserved region (InterPro:IPR018418); BEST Arabidopsis thaliana protein match is: sodium proton exchanger, putative (NHX7) (SOS1) (TAIR:AT2G01980.1); Has 7911 Blast hits to 7887 proteins in 1969 species: Archae - 132; Bacteria - 5569; Metazoa - 988; Fungi - 148; Plants - 408; Viruses - 0; Other Eukaryotes - 666 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    5031943..5036610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101333.5 → NP_172918.2  Na+/H+ exchanger 8 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_172918.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3YL57, Q9LQW7, Q9MA19
    UniProtKB/TrEMBL
    A0A5S9UGZ1, A0A7G2DQR3
    Conserved Domains (1) summary
    COG0025
    Location:30 → 463
    NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]

  2. NM_001198066.1 → NP_001184995.1  Na+/H+ exchanger 8 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001184995.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2DUR4, F4HW96
    Conserved Domains (2) summary
    TIGR00831
    Location:56 → 544
    a_cpa1; Na+/H+ antiporter, bacterial form
    COG0025
    Location:30 → 440
    NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3YL57.1

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