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CCMH cytochrome c biogenesis protein family [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838089, updated on 18-Sep-2024

Summary

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Official Symbol
CCMH
Official Full Name
cytochrome c biogenesis protein family
Primary source
TAIR:AT1G15220
Locus tag
AT1G15220
See related
Araport:AT1G15220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCCMH; F9L1.17; F9L1_17
Summary
Encodes a protein with oxidoreductase activity present in the inner membrane of mitochondria. CCMH is postulated to play a central role in mitochondrial cytochrome c maturation, probably as part of a heme lyase complex that also holds activity of reducing apocytochrome c. CCMH interacts with apocytochrome AtCYTc-a and is shown to be present in a 500 kDa-complex along with CcmFN2.
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Genomic context

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See CCMH in Genome Data Viewer
Location:
chromosome: 1
Exon count:
4
Sequence:
Chromosome: 1; NC_003070.9 (5240029..5241541, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene protein-protein interaction regulator family protein Neighboring gene pleiotropic drug resistance 7 Neighboring gene SAWADEE HOMEODOMAIN protein Neighboring gene uncharacterized protein Neighboring gene phox (PX) domain-containing protein Neighboring gene Zinc-binding ribosomal protein family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The three mitochondrial encoded CcmF proteins form a complex that interacts with CCMH and c-type apocytochromes in Arabidopsis. Rayapuram N, et al. J Biol Chem, 2008 Sep 12. PMID 18644794
  2. AtCCMH, an essential component of the c-type cytochrome maturation pathway in Arabidopsis mitochondria, interacts with apocytochrome c. Meyer EH, et al. Proc Natl Acad Sci U S A, 2005 Nov 1. PMID 16236729, Free PMC Article
  3. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CcmF and CCMH make a complex that performs the assembly of heme with c-type apocytochromes in plant mitochondria
    Title: The three mitochondrial encoded CcmF proteins form a complex that interacts with CCMH and c-type apocytochromes in Arabidopsis.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_101390.2
NM_202105.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytochrome complex assembly TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytochrome c biogenesis protein family
NP_563966.1
  • CCMH; CONTAINS InterPro DOMAIN/s: Cytochrome C biogenesis protein CcmH (InterPro:IPR005616); Has 3193 Blast hits to 3193 proteins in 721 species: Archae - 0; Bacteria - 1884; Metazoa - 0; Fungi - 0; Plants - 31; Viruses - 0; Other Eukaryotes - 1278 (source: NCBI BLink).
NP_973834.1
  • CCMH; CONTAINS InterPro DOMAIN/s: Cytochrome C biogenesis protein CcmH (InterPro:IPR005616); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    5240029..5241541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_202105.2 → NP_973834.1  cytochrome c biogenesis protein family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973834.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XI46
    UniProtKB/TrEMBL
    A0A178W6T6, A0A5S9UKR3
    Conserved Domains (1) summary
    pfam03918
    Location:14 → 132
    CcmH; Cytochrome C biogenesis protein

  2. NM_101390.2 → NP_563966.1  cytochrome c biogenesis protein family [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563966.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XI46
    UniProtKB/TrEMBL
    A0A178W6T6, A0A5S9UKR3
    Conserved Domains (1) summary
    pfam03918
    Location:14 → 132
    CcmH; Cytochrome C biogenesis protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XI46.1

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