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OR1A1 olfactory receptor family 1 subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 8383, updated on 27-Nov-2024

Summary

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Official Symbol
OR1A1provided by HGNC
Official Full Name
olfactory receptor family 1 subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:8179
See related
Ensembl:ENSG00000172146 MIM:618046; AllianceGenome:HGNC:8179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR17-7
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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See OR1A1 in Genome Data Viewer
Location:
17p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3207667..3218896)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3095937..3107165)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3110961..3122190)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100288728 Neighboring gene olfactory receptor family 1 subfamily P member 1 (gene/pseudogene) Neighboring gene olfactory receptor family 1 subfamily A member 2 Neighboring gene olfactory receptor family 1 subfamily D member 4 Neighboring gene olfactory receptor family 1 subfamily D member 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Third Extracellular Loop of Mammalian Odorant Receptors Is Involved in Ligand Binding. Shim T, et al. Int J Mol Sci, 2022 Oct 18. PMID 36293357, Free PMC Article
  2. Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds. Ahmed L, et al. Proc Natl Acad Sci U S A, 2018 Apr 24. PMID 29632183, Free PMC Article
  3. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. Schmiedeberg K, et al. J Struct Biol, 2007 Sep. PMID 17601748
  4. Activation of OR1A1 suppresses PPAR-γ expression by inducing HES-1 in cultured hepatocytes. Wu C, et al. Int J Biochem Cell Biol, 2015 Jul. PMID 25817041
  5. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. Glusman G, et al. Genomics, 2000 Jan 15. PMID 10673334

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Third Extracellular Loop of Mammalian Odorant Receptors Is Involved in Ligand Binding.
    Title: The Third Extracellular Loop of Mammalian Odorant Receptors Is Involved in Ligand Binding.
  2. Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds.
    Title: Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds.
  3. OR1A1 activation suppresses hepatic triglyceride metabolism by modulating HES-1, PPARG, and mtGPAT expression.
    Title: Activation of OR1A1 suppresses PPAR-γ expression by inducing HES-1 in cultured hepatocytes.
  4. Evolutionary conserved amino acid residues to be necessary for specific responsiveness of OR1A1 to odorants were identified.
    Title: Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
olfactory receptor 1A1
Names
olfactory receptor 17-7
olfactory receptor OR17-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386104.1 → NP_001373033.1  olfactory receptor 1A1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC090282
    Consensus CDS
    CCDS11022.1
    UniProtKB/Swiss-Prot
    A5D914, Q6IFM1, Q6NTA9, Q96R87, Q9P1Q5
    UniProtKB/TrEMBL
    A0A126GW88, A0A126GW98, A0A126GWA0, A0A126GWA2
    Related
    ENSP00000492897.1, ENST00000641322.1
    Conserved Domains (1) summary
    cd15235
    Location:24 → 299
    7tmA_OR1A-like; olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_014565.3 → NP_055380.2  olfactory receptor 1A1

    See identical proteins and their annotated locations for NP_055380.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC090282
    Consensus CDS
    CCDS11022.1
    UniProtKB/Swiss-Prot
    A5D914, Q6IFM1, Q6NTA9, Q96R87, Q9P1Q5
    UniProtKB/TrEMBL
    A0A126GW88, A0A126GW98, A0A126GWA0, A0A126GWA2
    Related
    ENSP00000493179.1, ENST00000641732.2
    Conserved Domains (1) summary
    cd15235
    Location:24 → 299
    7tmA_OR1A-like; olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    3207667..3218896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    3095937..3107165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P1Q5.2 GenPept UniProtKB/Swiss-Prot:Q9P1Q5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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