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DA1 DA1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838510, updated on 18-Sep-2024

Summary

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Official Symbol
DA1
Official Full Name
DA1
Primary source
TAIR:AT1G19270
Locus tag
AT1G19270
See related
Araport:AT1G19270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DA (large in Chinese) 1; T29M8.14; T29M8_14
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Genomic context

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See DA1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Sequence:
Chromosome: 1; NC_003070.9 (6662417..6666032)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene flavin-dependent monooxygenase 1 Neighboring gene TTF-type zinc finger protein with HAT dimerization domain-containing protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of final seed and organ size by the DA1 gene family in Arabidopsis thaliana. Li Y, et al. Genes Dev, 2008 May 15. PMID 18483219, Free PMC Article
  2. Modulation of receptor-like transmembrane kinase 1 nuclear localization by DA1 peptidases in Arabidopsis. Gu B, et al. Proc Natl Acad Sci U S A, 2022 Oct 4. PMID 36161927, Free PMC Article
  3. Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis. Dong H, et al. Genes Dev, 2017 Jan 15. PMID 28167503, Free PMC Article
  4. Forever Young: The Role of Ubiquitin Receptor DA1 and E3 Ligase BIG BROTHER in Controlling Leaf Growth and Development. Vanhaeren H, et al. Plant Physiol, 2017 Feb. PMID 28003326, Free PMC Article
  5. The ubiquitin receptor DA1 regulates seed and organ size by modulating the stability of the ubiquitin-specific protease UBP15/SOD2 in Arabidopsis. Du L, et al. Plant Cell, 2014 Feb. PMID 24585836, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The trxG protein ULT1 regulates Arabidopsis organ size by interacting with TCP14/15 to antagonize the LIM peptidase DA1 for H3K4me3 on target genes.
    Title: The trxG protein ULT1 regulates Arabidopsis organ size by interacting with TCP14/15 to antagonize the LIM peptidase DA1 for H3K4me3 on target genes.
  2. The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis.
    Title: The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis.
  3. Modulation of receptor-like transmembrane kinase 1 nuclear localization by DA1 peptidases in Arabidopsis.
    Title: Modulation of receptor-like transmembrane kinase 1 nuclear localization by DA1 peptidases in Arabidopsis.
  4. DA1 role in controlling leaf growth and senescence
    Title: Forever Young: The Role of Ubiquitin Receptor DA1 and E3 Ligase BIG BROTHER in Controlling Leaf Growth and Development.
  5. DA1 peptidase activity regulates the duration of cell proliferation and the transition to endoreduplication and differentiation during organ formation in plants by coordinating the destabilization of regulatory proteins.
    Title: Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis.
  6. DA1, DAR1, and DAR2 physically interact with the transcription factors TCP14 and TCP15, which repress endoreduplication.
    Title: The ubiquitin receptors DA1, DAR1, and DAR2 redundantly regulate endoreduplication by modulating the stability of TCP14/15 in Arabidopsis.
  7. Genetic analyses show that DA2 functions synergistically with DA1 to regulate seed size, but does so independently of EOD1. Further results reveal that DA2 interacts physically with DA1 in vitro and in vivo.
    Title: The ubiquitin receptor DA1 interacts with the E3 ubiquitin ligase DA2 to regulate seed and organ size in Arabidopsis.
  8. Genetic analyses indicate that UBP15 functions antagonistically in a common pathway with DA1 to influence seed size, but does so independently of DA2 and EOD1.
    Title: The ubiquitin receptor DA1 regulates seed and organ size by modulating the stability of the ubiquitin-specific protease UBP15/SOD2 in Arabidopsis.
  9. Overexpression of a da1-1 cDNA dramatically increases seed and organ size of wild-type plants.
    Title: Control of final seed and organ size by the DA1 gene family in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001332389.1
NM_101785.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within multidimensional cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plant ovule morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of leaf senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA endoreduplication IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of seed growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within seed morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
DA1
NP_173361.1
  • DA1 (DA1); CONTAINS InterPro DOMAIN/s: Zinc finger, LIM-type (InterPro:IPR001781), Ubiquitin interacting motif (InterPro:IPR003903), Protein of unknown function DUF3633 (InterPro:IPR022087); BEST Arabidopsis thaliana protein match is: LIM domain-containing protein (TAIR:AT4G36860.1); Has 3538 Blast hits to 2617 proteins in 167 species: Archae - 0; Bacteria - 18; Metazoa - 3009; Fungi - 63; Plants - 177; Viruses - 0; Other Eukaryotes - 271 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    6662417..6666032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101785.4 → NP_173361.1  DA1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173361.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0C7Q8, Q9LM99
    UniProtKB/TrEMBL
    A0A178WC71, A0A5S9V5C0
    Conserved Domains (3) summary
    cd09396
    Location:172 → 224
    LIM_DA1; The Lim domain of DA1
    PTZ00482
    Location:29 → 132
    PTZ00482; membrane-attack complex/perforin (MACPF) Superfamily; Provisional
    pfam12315
    Location:321 → 527
    DA1-like; Protein DA1

  2. NM_001332389.1 → NP_001320535.1  DA1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0C7Q8, Q9LM99
    UniProtKB/TrEMBL
    A0A178WC71, A0A5S9V5C0
    Conserved Domains (3) summary
    cd09396
    Location:172 → 224
    LIM_DA1; The Lim domain of DA1
    PTZ00482
    Location:29 → 132
    PTZ00482; membrane-attack complex/perforin (MACPF) Superfamily; Provisional
    pfam12315
    Location:321 → 527
    DA1-like; Protein DA1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C7Q8.1

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