SOG1 NAC (No Apical Meristem) domain transcriptional regulator superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SOG1
Official Full Name: NAC (No Apical Meristem) domain transcriptional regulator superfamily protein
Primary source: TAIR:AT1G25580
Locus tag: AT1G25580
See related: Araport:AT1G25580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ANAC008; Arabidopsis NAC domain containing protein 8; F2J7.1; SUPPRESSOR OF GAMMA RADIATION 1
Summary: Encodes suppressor of gamma response 1 (SOG1), a putative transcription factor governing multiple responses to DNA damage.
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Genomic context

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See SOG1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 6

Sequence:: Chromosome: 1; NC_003070.9 (8996714..8999917, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis cryptochromes interact with SOG1 to promote the repair of DNA double-strand breaks.
Title: Arabidopsis cryptochromes interact with SOG1 to promote the repair of DNA double-strand breaks.
SOG1 and BRCA1 Interdependently Regulate RAD54 Expression for Repairing Salinity-Induced DNA Double-Strand Breaks in Arabidopsis.
Title: SOG1 and BRCA1 Interdependently Regulate RAD54 Expression for Repairing Salinity-Induced DNA Double-Strand Breaks in Arabidopsis.
In silico scanning of structural and functional deleterious nsSNPs in Arabidopsis thaliana's SOG1 protein, using molecular dynamic simulation approaches.
Title: In silico scanning of structural and functional deleterious nsSNPs in Arabidopsis thaliana's SOG1 protein, using molecular dynamic simulation approaches.
Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage, inhibiting ATM/SOG1-mediated DNA damage response, and antagonizing global DNA hypermethylation.
Title: Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage, inhibiting ATM/SOG1-mediated DNA damage response, and antagonizing global DNA hypermethylation.
The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.
Title: The Arabidopsis ATR-SOG1 signaling module regulates pleiotropic developmental adjustments in response to 3'-blocked DNA repair intermediates.
both the N-terminal NAC domain and the C-terminal region of SOG1 have roles in regulating the stability of SOG1 protein under salinity stress in vitro
Title: An insight into the folding and stability of Arabidopsis thaliana SOG1 transcription factor under salinity stress in vitro.
These results suggest that SOG1 regulates crosstalk between DNA damage response and the immune response and that plants have evolved a sophisticated defense network to contend with environmental stress.
Title: SUPPRESSOR OF GAMMA RESPONSE 1 acts as a regulator coordinating crosstalk between DNA damage response and immune response in Arabidopsis thaliana.
SOG1, one of the newly identified components of DNA damage response in plant genome, appears to play central role in this signaling network. (Review)
Title: An insight into the mechanism of DNA damage response in plants- role of SUPPRESSOR OF GAMMA RESPONSE 1: An overview.
Together with the expected interaction of SOG1 with the promoter of NAC103, this study suggests that NAC103 is a putative SOG1-dependent transcriptional regulator of plant DNA damage response (DDR) genes, which are responsible for DDR phenotypes under genotoxic stress.
Title: SOG1-dependent NAC103 modulates the DNA damage response as a transcriptional regulator in Arabidopsis.
These results show that the extent of ser-gln phosphorylation in SOG1 regulates gene expression levels and determines the strength of DNA damage responses.
Title: Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_102369.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: NAC (No Apical Meristem) domain transcriptional regulator superfamily protein

NP_564238.2

SUPPRESSOR OF GAMMA RADIATION 1 (SOG1); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: multicellular organismal development, response to gamma radiation, DNA damage checkpoint, regulation of meiosis; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: No apical meristem (NAM) protein (InterPro:IPR003441); BEST Arabidopsis thaliana protein match is: NAC domain containing protein 85 (TAIR:AT5G14490.1); Has 2166 Blast hits to 2160 proteins in 77 species: Archae - 0; Bacteria - 0; Metazoa - 22; Fungi - 5; Plants - 2134; Viruses - 0; Other Eukaryotes - 5 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

8996714..8999917 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102369.3 → NP_564238.2 NAC (No Apical Meristem) domain transcriptional regulator superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564238.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NQK2, Q9C610, Q9C6M7

UniProtKB/TrEMBL

A0A178WLI1, A0A385HDR1, A0A5S9VVT3

Conserved Domains (1) summary

pfam02365
Location:59 → 192

NAM; No apical meristem (NAM) protein