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DCP5 decapping 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839152, updated on 6-Nov-2024

Summary

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Official Symbol
DCP5
Official Full Name
decapping 5
Primary source
TAIR:AT1G26110
Locus tag
AT1G26110
See related
Araport:AT1G26110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
decapping 5; F14G11.8; F14G11_8
Summary
Encodes Decapping 5, required for mRNA decapping, P-body formation and translational repression during postembryonic development.
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Genomic context

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See DCP5 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Sequence:
Chromosome: 1; NC_003070.9 (9024341..9027955, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene Cytochrome b561/ferric reductase transmembrane protein family Neighboring gene ncRNA Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene miscRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cytoplasmic osmosensing mechanism mediated by molecular crowding-sensitive DCP5. Wang Z, et al. Science, 2024 Nov. PMID 39480925
  2. The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis. Scheer H, et al. Nat Commun, 2021 Feb 26. PMID 33637717, Free PMC Article
  3. The P-body component DECAPPING5 and the floral repressor SISTER OF FCA regulate FLOWERING LOCUS C transcription in Arabidopsis. Wang W, et al. Plant Cell, 2023 Sep 1. PMID 37220754, Free PMC Article
  4. Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation. Xu J, et al. EMBO J, 2012 Apr 18. PMID 22407295, Free PMC Article
  5. Arabidopsis decapping 5 is required for mRNA decapping, P-body formation, and translational repression during postembryonic development. Xu J, et al. Plant Cell, 2009 Oct. PMID 19855049, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A cytoplasmic osmosensing mechanism mediated by molecular crowding-sensitive DCP5.
    Title: A cytoplasmic osmosensing mechanism mediated by molecular crowding-sensitive DCP5.
  2. The P-body component DECAPPING5 and the floral repressor SISTER OF FCA regulate FLOWERING LOCUS C transcription in Arabidopsis.
    Title: The P-body component DECAPPING5 and the floral repressor SISTER OF FCA regulate FLOWERING LOCUS C transcription in Arabidopsis.
  3. These results suggest that mRNA decapping through MPK6-DCP1-DCP5 pathway serves as a rapid response to dehydration stress in Arabidopsis.
    Title: Dehydration stress activates Arabidopsis MPK6 to signal DCP1 phosphorylation.
  4. In vitro experiments using wheat germ extracts confirmed that DCP5 is a translational repressor. Results showed that DCP5 is required for translational repression and P-body formation and plays an indirect role in mRNA decapping.
    Title: Arabidopsis decapping 5 is required for mRNA decapping, P-body formation, and translational repression during postembryonic development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001160895.1
NM_102376.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within P-body assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within deadenylation-independent decapping of nuclear-transcribed mRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytoplasmic mRNA processing body assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
decapping 5
NP_001154367.1
  • decapping 5 (DCP5); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: negative regulation of translation, deadenylation-independent decapping of nuclear-transcribed mRNA, cytoplasmic mRNA processing body assembly; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DFDF motif (InterPro:IPR019050), FFD/TFG box motif (InterPro:IPR019053); BEST Arabidopsis thaliana protein match is: decapping 5-like (TAIR:AT5G45330.1); Has 14874 Blast hits to 10327 proteins in 603 species: Archae - 12; Bacteria - 902; Metazoa - 6418; Fungi - 2978; Plants - 1226; Viruses - 261; Other Eukaryotes - 3077 (source: NCBI BLink).
NP_564239.1
  • decapping 5 (DCP5); CONTAINS InterPro DOMAIN/s: DFDF motif (InterPro:IPR019050), FFD/TFG box motif (InterPro:IPR019053); BEST Arabidopsis thaliana protein match is: decapping 5-like (TAIR:AT5G45330.1); Has 46741 Blast hits to 20189 proteins in 1086 species: Archae - 36; Bacteria - 10029; Metazoa - 17132; Fungi - 5632; Plants - 6968; Viruses - 649; Other Eukaryotes - 6295 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    9024341..9027955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_102376.4 → NP_564239.1  decapping 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564239.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DHI7, F4IE33, Q8RWC4, Q9ASU0, Q9C604, Q9C658
    UniProtKB/TrEMBL
    A0A178WFG5, A0A5S9VY65
    Conserved Domains (3) summary
    pfam07462
    Location:323 → 399
    MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus
    pfam09532
    Location:460 → 553
    FDF; FDF domain
    pfam12701
    Location:16 → 88
    LSM14; Scd6-like Sm domain

  2. NM_001160895.1 → NP_001154367.1  decapping 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154367.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WFG5, A0A5S9VY65
    Conserved Domains (3) summary
    pfam07462
    Location:323 → 399
    MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus
    pfam09532
    Location:454 → 547
    FDF; FDF domain
    pfam12701
    Location:16 → 88
    LSM14; Scd6-like Sm domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C658.1

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