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ABCC5 multidrug resistance-associated protein 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839277, updated on 28-Oct-2024

Summary

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Official Symbol
ABCC5
Official Full Name
multidrug resistance-associated protein 5
Primary source
TAIR:AT1G04120
Locus tag
AT1G04120
See related
Araport:AT1G04120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA ATP BINDING CASSETTE TRANSPORTER C5; Arabidopsis thaliana ATP-binding cassette C5; ATABCC5; ATMRP5; ATP BINDING CASSETTE TRANSPORTER C5; ATP-binding cassette C5; MULTIDRUG RESISTANCE PROTEIN 5; multidrug resistance-associated protein 5
Summary
encodes a high-affinity inositol hexakisphosphate transporter that plays a role in guard cell signaling and phytate storage. It is a member of MRP subfamily / ABC transporter subfamily C.
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Genomic context

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See ABCC5 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
12
Sequence:
Chromosome: 1; NC_003070.9 (1064264..1071080, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene indoleacetic acid-induced protein 10 Neighboring gene Subtilase family protein Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Transducin family protein / WD-40 repeat family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arabidopsis ATP-binding cassette protein AtMRP5/AtABCC5 is a high affinity inositol hexakisphosphate transporter involved in guard cell signaling and phytate storage. Nagy R, et al. J Biol Chem, 2009 Nov 27. PMID 19797057, Free PMC Article
  2. The ATP binding cassette transporter AtMRP5 modulates anion and calcium channel activities in Arabidopsis guard cells. Suh SJ, et al. J Biol Chem, 2007 Jan 19. PMID 17098742
  3. Binding of sulfonylurea by AtMRP5, an Arabidopsis multidrug resistance-related protein that functions in salt tolerance. Lee EK, et al. Plant Physiol, 2004 Jan. PMID 14684837, Free PMC Article
  4. Simultaneous mutations in ITPK4 and MRP5 genes result in a low phytic acid level without compromising salt tolerance in Arabidopsis. Ren Y, et al. J Integr Plant Biol, 2024 Oct. PMID 39031490
  5. The Arabidopsis thaliana ABC protein superfamily, a complete inventory. Sánchez-Fernández R, et al. J Biol Chem, 2001 Aug 10. PMID 11346655

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Simultaneous mutations in ITPK4 and MRP5 genes result in a low phytic acid level without compromising salt tolerance in Arabidopsis.
    Title: Simultaneous mutations in ITPK4 and MRP5 genes result in a low phytic acid level without compromising salt tolerance in Arabidopsis.
  2. Data demonstrate that AtMRP5 encodes a specific and high affinity ATP-dependent inositol hexakisphosphate transporter that is sensitive to inhibitors of ABC transporters.
    Title: The Arabidopsis ATP-binding cassette protein AtMRP5/AtABCC5 is a high affinity inositol hexakisphosphate transporter involved in guard cell signaling and phytate storage.
  3. AtMRP5 ABC transporter is a central regulator of guard cell ion channel during abscisic acid and Ca(2+) signal transduction in guard cells
    Title: The ATP binding cassette transporter AtMRP5 modulates anion and calcium channel activities in Arabidopsis guard cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001197977.1
NM_001331463.1
NM_100293.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ABC-type xenobiotic transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables sulfonylurea receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stomatal opening IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole HDA PubMed 
located_in vacuolar membrane HDA PubMed 
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
multidrug resistance-associated protein 5
NP_001184906.1
  • multidrug resistance-associated protein 5 (MRP5); CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 3 (TAIR:AT3G13080.1).
NP_171908.1
  • multidrug resistance-associated protein 5 (MRP5); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, sulfonylurea receptor activity; INVOLVED IN: response to salt stress, cellular potassium ion homeostasis; LOCATED IN: vacuolar membrane, plasma membrane, plant-type vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 3 (TAIR:AT3G13080.1); Has 705301 Blast hits to 367091 proteins in 4105 species: Archae - 12555; Bacteria - 572920; Metazoa - 12444; Fungi - 7893; Plants - 6883; Viruses - 23; Other Eukaryotes - 92583 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    1064264..1071080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100293.3 → NP_171908.1  multidrug resistance-associated protein 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_171908.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65619, Q56ZX0, Q7GB25
    UniProtKB/TrEMBL
    A0A178WGC2, A0A5S9SHA6
    Conserved Domains (1) summary
    TIGR00957
    Location:229 → 1493
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

  2. NM_001197977.1 → NP_001184906.1  multidrug resistance-associated protein 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001184906.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4I454
    Conserved Domains (4) summary
    cd03244
    Location:1266 → 1481
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:622 → 822
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:228 → 1489
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:951 → 1195
    ABC_membrane; ABC transporter transmembrane region

  3. NM_001331463.1 → NP_001322077.1  multidrug resistance-associated protein 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AT08
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7GB25.2

Gene LinkOut

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