RALF1 rapid alkalinization factor 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RALF1
Official Full Name: rapid alkalinization factor 1
Primary source: TAIR:AT1G02900
Locus tag: AT1G02900
See related: Araport:AT1G02900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATRALF1; F22D16.10; F22D16_10; RALF-LIKE 1; RALFL1; rapid alkalinization factor 1; RAPID ALKALINIZATION FACTOR 1
Summary: Member of a diversely expressed predicted peptide family showing sequence similarity to tobacco Rapid Alkalinization Factor (RALF), and is believed to play an essential role in the physiology of Arabidopsis. Consists of a single exon and is characterized by a conserved C-terminal motif and N-terminal signal peptide. Mediates Ca2+-dependent signaling.
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Genomic context

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See RALF1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (653604..654457, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Growth-inhibiting effects of the unconventional plant APYRASE 7 of Arabidopsis thaliana influences the LRX/RALF/FER growth regulatory module.
Title: Growth-inhibiting effects of the unconventional plant APYRASE 7 of Arabidopsis thaliana influences the LRX/RALF/FER growth regulatory module.
RALF1 peptide triggers biphasic root growth inhibition upstream of auxin biosynthesis.
Title: RALF1 peptide triggers biphasic root growth inhibition upstream of auxin biosynthesis.
The RALF1-FERONIA Complex Phosphorylates eIF4E1 to Promote Protein Synthesis and Polar Root Hair Growth.
Title: The RALF1-FERONIA Complex Phosphorylates eIF4E1 to Promote Protein Synthesis and Polar Root Hair Growth.
inter-relationships with the heterotrimeric Gbeta subunit AGB1 and FERONIA in salinity response
Title: Inter-relationships between the heterotrimeric Gβ subunit AGB1, the receptor-like kinase FERONIA, and RALF1 in salinity response.
Restoration of guard cell rapid alkalinization factor 1 (RALF1) responses by dereceptor-like kinase FERONIA (FER) is dose-dependent.
Title: A kinase-dead version of FERONIA receptor-like kinase has dose-dependent impacts on rosette morphology and RALF1-mediated stomatal movements.
We report here that, upon RALF1 binding, FER first promotes ErbB3-binding protein 1 (EBP1) mRNA translation and then interacts with and phosphorylates the EBP1 protein, leading to EBP1 accumulation in the nucleus.
Title: EBP1 nuclear accumulation negatively feeds back on FERONIA-mediated RALF1 signaling.
RALF1 role in stomatal movement regulation.
Title: The G Protein β-Subunit, AGB1, Interacts with FERONIA in RALF1-Regulated Stomatal Movement.
a new component of the AtRALF1 response pathway is a calmodulin-like protein that binds AtRALF1, is essential for root growth inhibition, and has no role in AtRALF1 alkalinization.
Title: Arabidopsis thaliana rapid alkalinization factor 1-mediated root growth inhibition is dependent on calmodulin-like protein 38.
RALF1 triggers the phosphorylation of both FER and RIPK in a mutually dependent manner
Title: Receptor kinase complex transmits RALF peptide signal to inhibit root growth in Arabidopsis.
suppression of RALF1 gene expression, similar to disruption of the FER gene, rendered plants hypersensitive to ABA. These results formulated a mechanism for ABA activation of FER and for cross-talk between ABA and peptide hormone RALF in the control of plant growth and responses to stress signals
Title: FERONIA interacts with ABI2-type phosphatases to facilitate signaling cross-talk between abscisic acid and RALF peptide in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_100171.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-cell signaling	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in root development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: rapid alkalinization factor 1

NP_171789.1

rapid alkalinization factor 1 (RALF1); CONTAINS InterPro DOMAIN/s: Rapid ALkalinization Factor (InterPro:IPR008801); BEST Arabidopsis thaliana protein match is: ralf-like 33 (TAIR:AT4G15800.1); Has 267 Blast hits to 267 proteins in 20 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 2; Plants - 265; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

653604..654457 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100171.3 → NP_171789.1 rapid alkalinization factor 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_171789.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SRY3

UniProtKB/TrEMBL

A0A178WER1, A0A5S9SBJ1

Conserved Domains (1) summary

cl23823
Location:45 → 119

RALF; Rapid ALkalinization Factor (RALF)