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CIPK23 CBL-interacting protein kinase 23 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839907, updated on 18-Sep-2024

Summary

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Official Symbol
CIPK23
Official Full Name
CBL-interacting protein kinase 23
Primary source
TAIR:AT1G30270
Locus tag
AT1G30270
See related
Araport:AT1G30270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCIPK23; CBL-interacting protein kinase 23; F12P21.6; F12P21_6; LKS1; LOW-K+-SENSITIVE 1; PKS17; SNF1-RELATED PROTEIN KINASE 3.23; SnRK3.23; SOS2-like protein kinase 17
Summary
Arabidopsis thaliana CBL-interacting protein kinase 23. CIPK23 serves as a positive regulator of the potassium transporter AKT1 by directly phosphorylating AKT1. CIPK23 is activated by the binding of two calcineurin B-like proteins, CBL1 and CBL9.
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Genomic context

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See CIPK23 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
14
Sequence:
Chromosome: 1; NC_003070.9 (10654800..10658924)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene galactosyltransferase family protein Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana. Inoue SI, et al. Plant J, 2020 Nov. PMID 32780529, Free PMC Article
  2. CIPK23 is involved in iron acquisition of Arabidopsis by affecting ferric chelate reductase activity. Tian Q, et al. Plant Sci, 2016 May. PMID 26993237
  3. The Kinase CIPK23 Inhibits Ammonium Transport in Arabidopsis thaliana. Straub T, et al. Plant Cell, 2017 Feb. PMID 28188265, Free PMC Article
  4. CHL1 functions as a nitrate sensor in plants. Ho CH, et al. Cell, 2009 Sep 18. PMID 19766570
  5. Phosphorylation by CIPK23 regulates the high-affinity Mn transporter NRAMP1 in Arabidopsis. Kosuth T, et al. FEBS Lett, 2023 Aug. PMID 37501385

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation by CIPK23 regulates the high-affinity Mn transporter NRAMP1 in Arabidopsis.
    Title: Phosphorylation by CIPK23 regulates the high-affinity Mn transporter NRAMP1 in Arabidopsis.
  2. CBL1/9-CIPK23-NRAMP1 axis regulates manganese toxicity.
    Title: CBL1/9-CIPK23-NRAMP1 axis regulates manganese toxicity.
  3. The CIPK23 protein kinase represses SLAC1-type anion channels in Arabidopsis guard cells and stimulates stomatal opening.
    Title: The CIPK23 protein kinase represses SLAC1-type anion channels in Arabidopsis guard cells and stimulates stomatal opening.
  4. STOP1 Regulates LKS1 Transcription and Coordinates K(+)/NH4(+) Balance in Arabidopsis Response to Low-K(+) Stress.
    Title: STOP1 Regulates LKS1 Transcription and Coordinates K(+)/NH(4)(+) Balance in Arabidopsis Response to Low-K(+) Stress.
  5. A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
    Title: A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
  6. CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.
    Title: CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.
  7. The findings uncover additional pleiotropic roles of STOP1 mediated by CIPK23, which regulates various ion transporters including those regulating K+-homeostasis, which may induce a trade-off between drought tolerance and other traits.
    Title: Sensitive to Proton Rhizotoxicity1 Regulates Salt and Drought Tolerance of Arabidopsis thaliana through Transcriptional Regulation of CIPK23.
  8. CIPK23 occupies a key position in controlling ion balance and ion homeostasis in the plant cell.
    Title: The Kinase CIPK23 Inhibits Ammonium Transport in Arabidopsis thaliana.
  9. using mutants in known dormancy-related genes [DELAY OF GERMINATION 1 (DOG1), MOTHER OF FLOWERING TIME (MFT), CBL-INTERACTING PROTEIN KINASE 23 (CIPK23) and PHYTOCHROME A (PHYA)] components of the circadian clock are shown to be involved in coordination of the annual seed dormancy cycle.
    Title: A laboratory simulation of Arabidopsis seed dormancy cycling provides new insight into its regulation by clock genes and the dormancy-related genes DOG1, MFT, CIPK23 and PHYA.
  10. CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
    Title: AtKC1 and CIPK23 Synergistically Modulate AKT1-Mediated Low-Potassium Stress Responses in Arabidopsis.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001332883.1
NM_001332884.1
NM_102766.6

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within potassium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of stomatal movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to nutrient IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in stomatal movement IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within stomatal movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  
located_in plastid HDA PubMed 

General protein information

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Preferred Names
CBL-interacting protein kinase 23
NP_564353.1
  • CBL-interacting protein kinase 23 (CIPK23); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: CBL-interacting protein kinase 9 (TAIR:AT1G01140.1); Has 132391 Blast hits to 130112 proteins in 4449 species: Archae - 167; Bacteria - 15551; Metazoa - 48688; Fungi - 13416; Plants - 32041; Viruses - 531; Other Eukaryotes - 21997 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    10654800..10658924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_102766.6 → NP_564353.1  CBL-interacting protein kinase 23 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564353.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93VD3, Q9C753
    UniProtKB/TrEMBL
    A0A178W2X4, A0A5S9WG58, A0A7G2DU57
    Conserved Domains (2) summary
    cd12195
    Location:334 → 449
    CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases
    cd14663
    Location:30 → 285
    STKc_SnRK3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3

  2. NM_001332883.1 → NP_001320726.1  CBL-interacting protein kinase 23 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ANQ5, A0A7G2DU57

  3. NM_001332884.1 → NP_001320727.1  CBL-interacting protein kinase 23 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W3M8, A0A1P8ANR3, A0A384KCC6, A0A7G2DU57
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93VD3.1

Gene LinkOut

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