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TOM2A tobamovirus multiplication 2A [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840133, updated on 18-Sep-2024

Summary

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Official Symbol
TOM2A
Official Full Name
tobamovirus multiplication 2A
Primary source
TAIR:AT1G32400
Locus tag
AT1G32400
See related
Araport:AT1G32400
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F5D14.17; F5D14_17; tobamovirus multiplication 2A
Summary
TOM2A encodes a 280 amino acid putative four-pass transmembrane protein with a C-terminal farnesylation signal, essential for efficient multiplication of tobacco mosaic viruses.
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Genomic context

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See TOM2A in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Sequence:
Chromosome: 1; NC_003070.9 (11689064..11691588, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Vacuolar protein sorting 55 (VPS55) family protein Neighboring gene pentatricopeptide (PPR) repeat-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subcellular localization of host and viral proteins associated with tobamovirus RNA replication. Hagiwara Y, et al. EMBO J, 2003 Jan 15. PMID 12514140, Free PMC Article
  2. Arabidopsis TOBAMOVIRUS MULTIPLICATION (TOM) 2 locus encodes a transmembrane protein that interacts with TOM1. Tsujimoto Y, et al. EMBO J, 2003 Jan 15. PMID 12514139, Free PMC Article
  3. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
  4. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
  5. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001036050.2
NM_102974.5
NM_202223.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plant-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
tobamovirus multiplication 2A
NP_001031127.1
  • tobamovirus multiplication 2A (TOM2A); FUNCTIONS IN: protein binding; INVOLVED IN: viral replication complex formation and maintenance; LOCATED IN: vacuole, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetraspanin (InterPro:IPR018499); BEST Arabidopsis thaliana protein match is: Tetraspanin family protein (TAIR:AT2G20230.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_564399.1
  • tobamovirus multiplication 2A (TOM2A); FUNCTIONS IN: protein binding; INVOLVED IN: viral replication complex formation and maintenance; LOCATED IN: vacuole, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetraspanin (InterPro:IPR018499); BEST Arabidopsis thaliana protein match is: Tetraspanin family protein (TAIR:AT2G20230.1); Has 929 Blast hits to 927 proteins in 94 species: Archae - 0; Bacteria - 0; Metazoa - 729; Fungi - 0; Plants - 163; Viruses - 0; Other Eukaryotes - 37 (source: NCBI BLink).
NP_973952.1
  • tobamovirus multiplication 2A (TOM2A); FUNCTIONS IN: protein binding; INVOLVED IN: viral replication complex formation and maintenance; LOCATED IN: vacuole, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetraspanin (InterPro:IPR018499); BEST Arabidopsis thaliana protein match is: Tetraspanin family protein (TAIR:AT2G20230.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    11689064..11691588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_102974.5 → NP_564399.1  tobamovirus multiplication 2A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564399.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q56Z79, Q9C5W7, Q9LQL8
    UniProtKB/TrEMBL
    A0A5S9WMX2
    Conserved Domains (1) summary
    pfam00335
    Location:19 → 163
    Tetraspannin; Tetraspanin family

  2. NM_001036050.2 → NP_001031127.1  tobamovirus multiplication 2A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031127.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q56Z79, Q9C5W7, Q9LQL8
    UniProtKB/TrEMBL
    A0A5S9WMX2
    Conserved Domains (1) summary
    pfam00335
    Location:19 → 163
    Tetraspannin; Tetraspanin family

  3. NM_202223.3 → NP_973952.1  tobamovirus multiplication 2A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973952.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q56Z79, Q9C5W7, Q9LQL8
    UniProtKB/TrEMBL
    A0A5S9WMX2
    Conserved Domains (1) summary
    pfam00335
    Location:19 → 163
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C5W7.1

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