Ralbp1 ralA binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ralbp1provided by RGD
Official Full Name: ralA binding protein 1provided by RGD
Primary source: RGD:621134
See related: EnsemblRapid:ENSRNOG00000013461 AllianceGenome:RGD:621134
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RIP1; RLIP76
Summary: Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including negative regulation of smooth muscle cell proliferation; regulation of intracellular signal transduction; and small GTPase-mediated signal transduction. Is active in Schaffer collateral - CA1 synapse. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 219.9), Adrenal (RPKM 168.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q37

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (112903289..112940093, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (105456425..105493235, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (113579107..113598477, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of RIP1-RIP3-mediated necroptosis attenuates renal fibrosis via Wnt3alpha/beta-catenin/GSK-3beta signaling in unilateral ureteral obstruction.
Title: Inhibition of RIP1-RIP3-mediated necroptosis attenuates renal fibrosis via Wnt3α/β-catenin/GSK-3β signaling in unilateral ureteral obstruction.
The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke.
Title: The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke.
Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury.
Title: Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury.
Phosphorylation of RIP1 is the essential molecular mechanism of necroptosis.
Title: Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro.
subarachnoid hemorrhage led to the upregulation of RIP1, RIP3, phosphorylated DRP1 and NLRP3 inflammasome
Title: RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage.
These results demonstrated that indole-3-carbinol could induce apoptosis of hepatic stellate cells through RIP1 K63 de-ubiquitination by upregulating deubiquitinase CYLD.
Title: Indole-3-Carbinol Induces Apoptosis of Hepatic Stellate Cells through K63 De-Ubiquitination of RIP1 in Rats.
We propose that NMDAR activation brings RalBP1 close to PSD-95 to promote the interaction of RalBP1-associated endocytic proteins with PSD-95-associated AMPARs.
Title: Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF416967 (e-PCR)
- UniSTS:249344

RH125071 (e-PCR)
- UniSTS:161893

D1S3693 (e-PCR)
- UniSTS:474271

RH80877 (e-PCR)
- UniSTS:88024

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type glutathione S-conjugate transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in doxorubicin transport	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Cdc42 protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IPI Inferred from Physical Interaction more info	PubMed
involved_in small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ralA-binding protein 1

Names: DNP-SG ATPase; cytocentrin; dinitrophenyl S-glutathione ATPase; ral-interacting protein 1

NP_001380593.1

EC 7.6.2.2

EC 7.6.2.3

NP_114456.2

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393664.1 → NP_001380593.1 ralA-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O55195, Q62796

UniProtKB/TrEMBL

A0A0G2K694, A0A9K3Y7X7, Q5FVT1

Conserved Domains (2) summary

cd04381
Location:190 → 371

RhoGap_RalBP1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently ...

TIGR02168
Location:395 → 594

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_032067.2 → NP_114456.2 ralA-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

O55195, Q62796

UniProtKB/TrEMBL

A0A0G2K694, A0A9K3Y7X7, Q5FVT1

Related

ENSRNOP00000073726.2, ENSRNOT00000084884.3

Conserved Domains (2) summary

cd04381
Location:190 → 371

RhoGap_RalBP1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently ...

TIGR02168
Location:395 → 594

SMC_prok_B; chromosome segregation protein SMC, common bacterial type