Pnliprp1 pancreatic lipase-related protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pnliprp1provided by RGD
Official Full Name: pancreatic lipase-related protein 1provided by RGD
Primary source: RGD:620792
See related: EnsemblRapid:ENSRNOG00000017908 AllianceGenome:RGD:620792
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables lipase activity. Involved in pancreas development; response to glucocorticoid; and response to peptide hormone. Located in extracellular space. Orthologous to human PNLIPRP1 (pancreatic lipase related protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 3818.0) and Liver (RPKM 1444.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (267854027..267869654)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (257867885..257883514)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (279867034..279882663)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables lipase activity	ISO Inferred from Sequence Orthology more info
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pancreas development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
NOT located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inactive pancreatic lipase-related protein 1

Names: PL-RP1

NP_114470.1

EC 3.1.1.3

XP_063131831.1

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032081.1 → NP_114470.1 inactive pancreatic lipase-related protein 1 precursor

See identical proteins and their annotated locations for NP_114470.1

Status: PROVISIONAL

Source sequence(s)

X61925

UniProtKB/Swiss-Prot

P54316

UniProtKB/TrEMBL

A6JI67, G3V8A9

Related

ENSRNOP00000024164.4, ENSRNOT00000024164.6

Conserved Domains (2) summary

cd01759
Location:356 → 467

PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

pfam00151
Location:18 → 353

Lipase