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STOP1 C2H2 and C2HC zinc fingers superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840339, updated on 18-Sep-2024

Summary

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Official Symbol
STOP1
Official Full Name
C2H2 and C2HC zinc fingers superfamily protein
Primary source
TAIR:AT1G34370
Locus tag
AT1G34370
See related
Araport:AT1G34370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtSTOP1; F7P12.7; F7P12_7; sensitive to proton rhizotoxicity 1
Summary
Encodes a putative nuclear Cys(2)His(2)-type zinc finger protein involved in H+ and Al3+ rhizotoxicity. In mutants exposed to aluminum stress, there is no induction of AtALMT1, an malate transporter known to be involved in the mediation of aluminum toxicity. Cell wall of the mutant is unstable in low pH medium (pH 4.5) in low Ca solution. This would mediate Ca-alleviation of low pH stress through pectin-Ca interaction.
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Genomic context

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See STOP1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (12550339..12552629)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene forkhead-associated (FHA) domain-containing protein Neighboring gene translation initiation factor 3 (IF-3) family protein Neighboring gene ncRNA Neighboring gene 5'-3' exonuclease family protein Neighboring gene auxin response factor 22

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Zinc finger protein STOP1 is critical for proton tolerance in Arabidopsis and coregulates a key gene in aluminum tolerance. Iuchi S, et al. Proc Natl Acad Sci U S A, 2007 Jun 5. PMID 17535918, Free PMC Article
  2. STOP1 regulatory system: Centered on multiple stress tolerance and cellular nutrient management. Koyama H, et al. Mol Plant, 2021 Oct 4. PMID 34438056
  3. Synergistic and antagonistic pleiotropy of STOP1 in stress tolerance. Sadhukhan A, et al. Trends Plant Sci, 2021 Oct. PMID 34253485
  4. STOP1 regulates multiple genes that protect arabidopsis from proton and aluminum toxicities. Sawaki Y, et al. Plant Physiol, 2009 May. PMID 19321711, Free PMC Article
  5. Arabidopsis transcription factor STOP1 directly activates expression of NOD26-LIKE MAJOR INTRINSIC PROTEIN5;1, and is involved in the regulation of tolerance to low-boron stress. Zhang C, et al. J Exp Bot, 2024 Apr 15. PMID 38307018

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis transcription factor STOP1 directly activates expression of NOD26-LIKE MAJOR INTRINSIC PROTEIN5;1, and is involved in the regulation of tolerance to low-boron stress.
    Title: Arabidopsis transcription factor STOP1 directly activates expression of NOD26-LIKE MAJOR INTRINSIC PROTEIN5;1, and is involved in the regulation of tolerance to low-boron stress.
  2. STOP1 Regulates LKS1 Transcription and Coordinates K(+)/NH4(+) Balance in Arabidopsis Response to Low-K(+) Stress.
    Title: STOP1 Regulates LKS1 Transcription and Coordinates K(+)/NH(4)(+) Balance in Arabidopsis Response to Low-K(+) Stress.
  3. Root responses to aluminium and iron stresses require the SIZ1 SUMO ligase to modulate the STOP1 transcription factor.
    Title: Root responses to aluminium and iron stresses require the SIZ1 SUMO ligase to modulate the STOP1 transcription factor.
  4. A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
    Title: A transcription factor STOP1-centered pathway coordinates ammonium and phosphate acquisition in Arabidopsis.
  5. STOP1 regulatory system: Centered on multiple stress tolerance and cellular nutrient management.
    Title: STOP1 regulatory system: Centered on multiple stress tolerance and cellular nutrient management.
  6. STOP1 activates NRT1.1-mediated nitrate uptake to create a favorable rhizospheric pH for plant adaptation to acidity.
    Title: STOP1 activates NRT1.1-mediated nitrate uptake to create a favorable rhizospheric pH for plant adaptation to acidity.
  7. Synergistic and antagonistic pleiotropy of STOP1 in stress tolerance.
    Title: Synergistic and antagonistic pleiotropy of STOP1 in stress tolerance.
  8. The SUMO E3 ligase SIZ1 partially regulates STOP1 SUMOylation and stability in Arabidopsis thaliana.
    Title: The SUMO E3 ligase SIZ1 partially regulates STOP1 SUMOylation and stability in Arabidopsis thaliana.
  9. Degradation of STOP1 mediated by the F-box proteins RAH1 and RAE1 balances aluminum resistance and plant growth in Arabidopsis thaliana.
    Title: Degradation of STOP1 mediated by the F-box proteins RAH1 and RAE1 balances aluminum resistance and plant growth in Arabidopsis thaliana.
  10. High affinity promoter binding of STOP1 is essential for early expression of novel aluminum-induced resistance genes GDH1 and GDH2 in Arabidopsis.
    Title: High affinity promoter binding of STOP1 is essential for early expression of novel aluminum-induced resistance genes GDH1 and GDH2 in Arabidopsis.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001333101.1
NM_103160.5
NM_179415.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to oxygen levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to salt stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to acidic pH IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to aluminum ion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to aluminum ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to aluminum ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
C2H2 and C2HC zinc fingers superfamily protein
NP_001319144.1
  • sensitive to proton rhizotoxicity 1 (STOP1); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087), Zinc finger, double-stranded RNA binding (InterPro:IPR022755); BEST Arabidopsis thaliana protein match is: C2H2 and C2HC zinc fingers superfamily protein (TAIR:AT5G22890.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_174697.1
  • sensitive to proton rhizotoxicity 1 (STOP1); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: C2H2 and C2HC zinc fingers superfamily protein (TAIR:AT5G22890.1); Has 25295 Blast hits to 14002 proteins in 194 species: Archae - 0; Bacteria - 2; Metazoa - 23814; Fungi - 97; Plants - 697; Viruses - 0; Other Eukaryotes - 685 (source: NCBI BLink).
NP_849746.1
  • sensitive to proton rhizotoxicity 1 (STOP1); CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: C2H2 and C2HC zinc fingers superfamily protein (TAIR:AT5G22890.1); Has 25295 Blast hits to 14002 proteins in 194 species: Archae - 0; Bacteria - 2; Metazoa - 23814; Fungi - 97; Plants - 697; Viruses - 0; Other Eukaryotes - 685 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    12550339..12552629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_103160.5 → NP_174697.1  C2H2 and C2HC zinc fingers superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174697.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5A8C1, Q8LA79, Q9C8N5
    UniProtKB/TrEMBL
    A0A178WM47, A0A5S9WLR3
    Conserved Domains (3) summary
    sd00017
    Location:246 → 266
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:363 → 379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:244 → 266
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_001333101.1 → NP_001319144.1  C2H2 and C2HC zinc fingers superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0Z277, Q2V4J0

  3. NM_179415.1 → NP_849746.1  C2H2 and C2HC zinc fingers superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849746.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5A8C1, Q8LA79, Q9C8N5
    UniProtKB/TrEMBL
    A0A178WM47, A0A5S9WLR3
    Conserved Domains (3) summary
    sd00017
    Location:246 → 266
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:363 → 379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:244 → 266
    zf-C2H2; Zinc finger, C2H2 type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C8N5.1

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