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mtLPD1 mitochondrial lipoamide dehydrogenase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841221, updated on 18-Sep-2024

Summary

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Official Symbol
mtLPD1
Official Full Name
mitochondrial lipoamide dehydrogenase 1
Primary source
TAIR:AT1G48030
Locus tag
AT1G48030
See related
Araport:AT1G48030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
mitochondrial lipoamide dehydrogenase 1; T2J15.6
Summary
Encodes a mitochondrial lipoamide dehydrogenase whose expression is induced by light.
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Genomic context

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See mtLPD1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
2
Sequence:
Chromosome: 1; NC_003070.9 (17716893..17719500, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene pectin methylesterase inhibitor 1 Neighboring gene Protein phosphatase 2C family protein Neighboring gene Ku80 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of two cDNAs encoding mitochondrial lipoamide dehydrogenase from Arabidopsis. Lutziger I, et al. Plant Physiol, 2001 Oct. PMID 11598235, Free PMC Article
  2. Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana. Timm S, et al. Plant Cell, 2015 Jul. PMID 26116608, Free PMC Article
  3. Leaf proteome responses of Arabidopsis thaliana exposed to mild cadmium stress. Semane B, et al. J Plant Physiol, 2010 Mar 1. PMID 20005002
  4. Identification and molecular properties of SUMO-binding proteins in Arabidopsis. Park HC, et al. Mol Cells, 2011 Aug. PMID 21607647, Free PMC Article
  5. Internal architecture of mitochondrial complex I from Arabidopsis thaliana. Klodmann J, et al. Plant Cell, 2010 Mar. PMID 20197505, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of mtLPD improves photosynthesis and, in turn, biomass accumulation in Arabidopsis. [mtLPD1]
    Title: Mitochondrial Dihydrolipoyl Dehydrogenase Activity Shapes Photosynthesis and Photorespiration of Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001333289.1
NM_001333290.1
NM_001333291.1
NM_103699.5
NM_179451.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding HDA PubMed 
enables cobalt ion binding HDA PubMed 
enables copper ion binding HDA PubMed 
enables dihydrolipoyl dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding HDA PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in Golgi apparatus RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in apoplast HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in nucleus HDA PubMed 
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial lipoamide dehydrogenase 1
NP_175237.1
  • mitochondrial lipoamide dehydrogenase 1 (mtLPD1); FUNCTIONS IN: dihydrolipoyl dehydrogenase activity, copper ion binding, cobalt ion binding, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion, response to light stimulus; LOCATED IN: mitochondrion, apoplast, mitochondrial respiratory chain complex I, mitochondrial matrix; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Mercuric reductase (InterPro:IPR000815), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: lipoamide dehydrogenase 2 (TAIR:AT3G17240.3); Has 41363 Blast hits to 41324 proteins in 3251 species: Archae - 1062; Bacteria - 30027; Metazoa - 916; Fungi - 551; Plants - 652; Viruses - 0; Other Eukaryotes - 8155 (source: NCBI BLink).
NP_849782.1
  • lipoamide dehydrogenase 1 (LPD1); FUNCTIONS IN: dihydrolipoyl dehydrogenase activity, copper ion binding, cobalt ion binding, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion, response to light stimulus; LOCATED IN: mitochondrion, apoplast, mitochondrial respiratory chain complex I, mitochondrial matrix; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Mercuric reductase (InterPro:IPR000815), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: lipoamide dehydrogenase 2 (TAIR:AT3G17240.3); Has 41519 Blast hits to 41478 proteins in 3269 species: Archae - 1065; Bacteria - 30177; Metazoa - 918; Fungi - 552; Plants - 652; Viruses - 0; Other Eukaryotes - 8155 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    17716893..17719500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_103699.5 → NP_175237.1  mitochondrial lipoamide dehydrogenase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175237.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LNF3, Q9M5K3
    UniProtKB/TrEMBL
    A0A178W162, A0A5S9WML4
    Conserved Domains (1) summary
    cl39093
    Location:41 → 507
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  2. NM_001333289.1 → NP_001322048.1  mitochondrial lipoamide dehydrogenase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LNF3, Q9M5K3
    UniProtKB/TrEMBL
    A0A178W162, A0A5S9WML4
    Conserved Domains (1) summary
    cl39093
    Location:41 → 507
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  3. NM_001333291.1 → NP_001322047.1  mitochondrial lipoamide dehydrogenase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LNF3, Q9M5K3
    UniProtKB/TrEMBL
    A0A178W162, A0A5S9WML4
    Conserved Domains (1) summary
    cl39093
    Location:41 → 507
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  4. NM_001333290.1 → NP_001322049.1  mitochondrial lipoamide dehydrogenase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LNF3, Q9M5K3
    UniProtKB/TrEMBL
    A0A178W162, A0A5S9WML4
    Conserved Domains (1) summary
    cl39093
    Location:41 → 507
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  5. NM_179451.1 → NP_849782.1  mitochondrial lipoamide dehydrogenase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849782.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LNF3, Q9M5K3
    UniProtKB/TrEMBL
    A0A178W162, A0A5S9WML4
    Conserved Domains (1) summary
    cl39093
    Location:41 → 507
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9M5K3.2

Gene LinkOut

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