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THFS 10-formyltetrahydrofolate synthetase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841470, updated on 18-Sep-2024

Summary

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Official Symbol
THFS
Official Full Name
10-formyltetrahydrofolate synthetase
Primary source
TAIR:AT1G50480
Locus tag
AT1G50480
See related
Araport:AT1G50480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
10-formyltetrahydrofolate synthetase; 10-FORMYLTETRAHYDROFOLATE SYNTHETASE; F11F12.17
Summary
10-formyltetrahydrofolate synthetase (THFS) mRNA, complete
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Genomic context

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See THFS in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (18701882..18704938)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene hexokinase-like 1 Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene ubiquitin-conjugating enzyme 20 Neighboring gene Membrane trafficking VPS53 family protein Neighboring gene indigoidine synthase A family protein Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 27 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteomic survey of copper-binding proteins in Arabidopsis roots by immobilized metal affinity chromatography and mass spectrometry. Kung CC, et al. Proteomics, 2006 May. PMID 16526091
  2. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
  3. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
  4. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
  5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_103931.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables copper ion binding HDA PubMed 
enables formate-tetrahydrofolate ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
10-formyltetrahydrofolate synthetase
NP_564571.1
  • 10-formyltetrahydrofolate synthetase (THFS); FUNCTIONS IN: formate-tetrahydrofolate ligase activity, copper ion binding, ATP binding; INVOLVED IN: response to cadmium ion, folic acid and derivative biosynthetic process; LOCATED IN: apoplast, chloroplast, plasma membrane; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Formate-tetrahydrofolate ligase, FTHFS, conserved site (InterPro:IPR020628), Formate-tetrahydrofolate ligase, FTHFS (InterPro:IPR000559); BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT2G12280.1); Has 7211 Blast hits to 7172 proteins in 1581 species: Archae - 30; Bacteria - 3794; Metazoa - 307; Fungi - 186; Plants - 64; Viruses - 0; Other Eukaryotes - 2830 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    18701882..18704938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_103931.4 → NP_564571.1  10-formyltetrahydrofolate synthetase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564571.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SPK5
    UniProtKB/TrEMBL
    A0A178WCW8
    Conserved Domains (1) summary
    PLN02759
    Location:1 → 634
    PLN02759; Formate--tetrahydrofolate ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SPK5.1

Gene LinkOut

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