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TTL1 tetratricopetide-repeat thioredoxin-like 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841764, updated on 18-Sep-2024

Summary

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Official Symbol
TTL1
Official Full Name
tetratricopetide-repeat thioredoxin-like 1
Primary source
TAIR:AT1G53300
Locus tag
AT1G53300
See related
Araport:AT1G53300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F12M16.20; F12M16_20; tetratricopeptide-repeat thioredoxin-like 1; tetratricopetide-repeat thioredoxin-like 1
Summary
Encodes one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones. The TTL family is required for osmotic stress tolerance and male sporogenesis.
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Genomic context

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See TTL1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Sequence:
Chromosome: 1; NC_003070.9 (19879405..19882895)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene plant thionin family protein Neighboring gene Galactosyltransferase family protein Neighboring gene phosphoenolpyruvate carboxylase 1 Neighboring gene tubby like protein 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arabidopsis TETRATRICOPEPTIDE THIOREDOXIN-LIKE 1 Gene Is Involved in Anisotropic Root Growth during Osmotic Stress Adaptation. Cuadrado-Pedetti MB, et al. Genes (Basel), 2021 Feb 7. PMID 33562207, Free PMC Article
  2. The Arabidopsis tetratricopeptide repeat-containing protein TTL1 is required for osmotic stress responses and abscisic acid sensitivity. Rosado A, et al. Plant Physiol, 2006 Nov. PMID 16998088, Free PMC Article
  3. The Arabidopsis tetratricopeptide thioredoxin-like gene family is required for osmotic stress tolerance and male sporogenesis. Lakhssassi N, et al. Plant Physiol, 2012 Mar. PMID 22232384, Free PMC Article
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Arabidopsis TETRATRICOPEPTIDE THIOREDOXIN-LIKE 1 Gene Is Involved in Anisotropic Root Growth during Osmotic Stress Adaptation.
    Title: The Arabidopsis TETRATRICOPEPTIDE THIOREDOXIN-LIKE 1 Gene Is Involved in Anisotropic Root Growth during Osmotic Stress Adaptation.
  2. TTL1 was identified as a positive regulator of abscisic signaling during germination and seedling development under stress.
    Title: The Arabidopsis tetratricopeptide repeat-containing protein TTL1 is required for osmotic stress responses and abscisic acid sensitivity.
Submit: New GeneRIF Correction

General gene information

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NM_104208.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to abscisic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
tetratricopetide-repeat thioredoxin-like 1
NP_175737.1
  • tetratricopetide-repeat thioredoxin-like 1 (TTL1); FUNCTIONS IN: binding; INVOLVED IN: cell redox homeostasis; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Molecular chaperone, heat shock protein, Hsp40, DnaJ (InterPro:IPR015609), Tetratricopeptide TPR-1 (InterPro:IPR001440), Thioredoxin fold (InterPro:IPR012335), Tetratricopeptide-like helical (InterPro:IPR011990), Thioredoxin domain (InterPro:IPR013766), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: tetratricopetide-repeat thioredoxin-like 2 (TAIR:AT3G14950.1); Has 32097 Blast hits to 15852 proteins in 1300 species: Archae - 552; Bacteria - 6287; Metazoa - 8110; Fungi - 3609; Plants - 2668; Viruses - 128; Other Eukaryotes - 10743 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    19879405..19882895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_104208.3 → NP_175737.1  tetratricopetide-repeat thioredoxin-like 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175737.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9MAH1
    UniProtKB/TrEMBL
    A0A178W6A1, A0A5S9WP96
    Conserved Domains (5) summary
    smart00028
    Location:499 → 532
    TPR; Tetratricopeptide repeats
    cd02947
    Location:604 → 691
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    sd00006
    Location:469 → 493
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:468 → 530
    TPR_11; TPR repeat
    pfam13431
    Location:284 → 316
    TPR_17; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MAH1.1

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