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MUM4 NAD-dependent epimerase/dehydratase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841785, updated on 18-Sep-2024

Summary

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Official Symbol
MUM4
Official Full Name
NAD-dependent epimerase/dehydratase family protein
Primary source
TAIR:AT1G53500
Locus tag
AT1G53500
See related
Araport:AT1G53500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA MUCILAGE-MODIFIED 4; ARABIDOPSIS THALIANA RHAMNOSE BIOSYNTHESIS 2; ATMUM4; ATRHM2; F22G10.13; MUCILAGE-MODIFIED 4; RHAMNOSE BIOSYNTHESIS 2; RHM2
Summary
encodes a putative NDP-L-rhamnose synthase, an enzyme required for the synthesis of the pectin rhamnogalacturonan I, the major component of Arabidopsis mucilage. Gene is involved in seed coat mucilage cell development. Mutant analyses suggest that MUM4 is required for complete mucilage synthesis, cytoplasmic rearrangement and seed coat development.
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Genomic context

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See MUM4 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Sequence:
Chromosome: 1; NC_003070.9 (19966944..19969757, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene mechanosensitive channel of small conductance-like 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING/U-box superfamily protein Neighboring gene mto 1 responding down 1 Neighboring gene ncRNA Neighboring gene mitogen-activated protein kinase 18 Neighboring gene Chalcone-flavanone isomerase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a seed coat-specific promoter fragment from the Arabidopsis MUCILAGE-MODIFIED4 gene. Dean GH, et al. Plant Mol Biol, 2017 Sep. PMID 28730525
  2. MUCILAGE-MODIFIED4 encodes a putative pectin biosynthetic enzyme developmentally regulated by APETALA2, TRANSPARENT TESTA GLABRA1, and GLABRA2 in the Arabidopsis seed coat. Western TL, et al. Plant Physiol, 2004 Jan. PMID 14701918, Free PMC Article
  3. RHM2 is involved in mucilage pectin synthesis and is required for the development of the seed coat in Arabidopsis. Usadel B, et al. Plant Physiol, 2004 Jan. PMID 14671019, Free PMC Article
  4. LASSO modeling of the Arabidopsis thaliana seed/seedling transcriptome: a model case for detection of novel mucilage and pectin metabolism genes. Vasilevski A, et al. Mol Biosyst, 2012 Oct. PMID 22735692
  5. Arabidopsis glabra2 mutant seeds deficient in mucilage biosynthesis produce more oil. Shi L, et al. Plant J, 2012 Jan. PMID 21883555

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis and Camelina sativa, and is regulated by the same transcription factor cascade as endogenous MUM4.
    Title: Identification of a seed coat-specific promoter fragment from the Arabidopsis MUCILAGE-MODIFIED4 gene.
  2. Transcription factor GL2 and RHM2 are critical for the biosynthesis of mucilage pectin.
    Title: LASSO modeling of the Arabidopsis thaliana seed/seedling transcriptome: a model case for detection of novel mucilage and pectin metabolism genes.
  3. A target of GL2 in the seed coat is the gene MUM4 and GL2 regulates seed oil production at least partly through its influence on MUM4 expression in the seed coat.
    Title: Arabidopsis glabra2 mutant seeds deficient in mucilage biosynthesis produce more oil.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_104228.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity TAS
Traceable Author Statement
more info
 PubMed 
enables UDP-4-keto-rhamnose-4-keto-reductase activity TAS
Traceable Author Statement
more info
 PubMed 
enables UDP-L-rhamnose synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-L-rhamnose synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables UDP-glucose 4,6-dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dTDP-glucose 4,6-dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within UDP-rhamnose biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mucilage biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within seed coat development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
NAD-dependent epimerase/dehydratase family protein
NP_564633.2
  • MUCILAGE-MODIFIED 4 (MUM4); FUNCTIONS IN: UDP-4-keto-rhamnose-4-keto-reductase activity, UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity, catalytic activity, UDP-glucose 4,6-dehydratase activity, UDP-L-rhamnose synthase activity; INVOLVED IN: seed coat development, UDP-rhamnose biosynthetic process, mucilage biosynthetic process, metabolic process; LOCATED IN: soluble fraction; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), dTDP-4-dehydrorhamnose reductase (InterPro:IPR005913); BEST Arabidopsis thaliana protein match is: rhamnose biosynthesis 3 (TAIR:AT3G14790.1); Has 53909 Blast hits to 53717 proteins in 3029 species: Archae - 941; Bacteria - 31079; Metazoa - 1146; Fungi - 539; Plants - 1500; Viruses - 107; Other Eukaryotes - 18597 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    19966944..19969757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_104228.3 → NP_564633.2  NAD-dependent epimerase/dehydratase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564633.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LPG6
    UniProtKB/TrEMBL
    A0A178W591, A0A5S9WPC0, A0A5S9XDL2
    Conserved Domains (1) summary
    PLN02260
    Location:3 → 667
    PLN02260; probable rhamnose biosynthetic enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LPG6.1

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