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ALA3 aminophospholipid ATPase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842275, updated on 18-Sep-2024

Summary

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Official Symbol
ALA3
Official Full Name
aminophospholipid ATPase 3
Primary source
TAIR:AT1G59820
Locus tag
AT1G59820
See related
Araport:AT1G59820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
aminophospholipid ATPase 3; F23H11.14; F23H11_14
Summary
Encodes a phospholipid translocase. Involved in secretory vesicle formation from trans-Golgi in peripheral columella cells at the root tip. Mutants have short primary roots and grow slower.
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Genomic context

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See ALA3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
27
Sequence:
Chromosome: 1; NC_003070.9 (22011305..22020386)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene AGAMOUS-like 50 Neighboring gene protein phosphatase 2A-2 Neighboring gene Defensin-like (DEFL) family protein Neighboring gene DNA-directed RNA polymerase II subunit RPB1-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Tip-Localized Phosphatidylserine Established by Arabidopsis ALA3 Is Crucial for Rab GTPase-Mediated Vesicle Trafficking and Pollen Tube Growth. Zhou Y, et al. Plant Cell, 2020 Oct. PMID 32817253, Free PMC Article
  2. Loss of the Arabidopsis thaliana P₄-ATPase ALA3 reduces adaptability to temperature stresses and impairs vegetative, pollen, and ovule development. McDowell SC, et al. PLoS One, 2013. PMID 23667493, Free PMC Article
  3. IRREGULAR TRICHOME BRANCH 2 (ITB2) encodes a putative aminophospholipid translocase that regulates trichome branch elongation in Arabidopsis. Zhang X, et al. Plant J, 2009 Oct. PMID 19566596
  4. An Arabidopsis Lipid Flippase Is Required for Timely Recruitment of Defenses to the Host-Pathogen Interface at the Plant Cell Surface. Underwood W, et al. Mol Plant, 2017 Jun 5. PMID 28434950
  5. The Arabidopsis P4-ATPase ALA3 localizes to the golgi and requires a beta-subunit to function in lipid translocation and secretory vesicle formation. Poulsen LR, et al. Plant Cell, 2008 Mar. PMID 18344284, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A genome-wide association study identifies novel players in Na and Fe homeostasis in Arabidopsis thaliana under alkaline-salinity stress.
    Title: A genome-wide association study identifies novel players in Na and Fe homeostasis in Arabidopsis thaliana under alkaline-salinity stress.
  2. The Tip-Localized Phosphatidylserine Established by Arabidopsis ALA3 Is Crucial for Rab GTPase-Mediated Vesicle Trafficking and Pollen Tube Growth.
    Title: The Tip-Localized Phosphatidylserine Established by Arabidopsis ALA3 Is Crucial for Rab GTPase-Mediated Vesicle Trafficking and Pollen Tube Growth.
  3. ALA3 functions to modify endomembranes in multiple cell types
    Title: Loss of the Arabidopsis thaliana P₄-ATPase ALA3 reduces adaptability to temperature stresses and impairs vegetative, pollen, and ovule development.
  4. Mutations in ALA3 reduce trichome branch lengths, distort trichome shape, reduce primary root growth and increase root hair length.
    Title: IRREGULAR TRICHOME BRANCH 2 (ITB2) encodes a putative aminophospholipid translocase that regulates trichome branch elongation in Arabidopsis.
  5. Data show that ALA3 localizes to the Golgi apparatus and that mutations of ALA3 result in impaired growth of roots and shoots.
    Title: The Arabidopsis P4-ATPase ALA3 localizes to the golgi and requires a beta-subunit to function in lipid translocation and secretory vesicle formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_104675.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type ion transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables aminophospholipid flippase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminophospholipid flippase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within Golgi vesicle budding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen tube growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen tube guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization involved in auxin polar transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein localization involved in auxin polar transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to molecule of bacterial origin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to molecule of fungal origin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within shoot system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome HDA PubMed 
located_in nucleus HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pollen tube tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network HDA PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aminophospholipid ATPase 3
NP_176191.1
  • aminophospholipid ATPase 3 (ALA3); FUNCTIONS IN: phospholipid transporter activity, ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; INVOLVED IN: Golgi vesicle budding, shoot development, root development; LOCATED IN: Golgi apparatus, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, phospholipid-translocating, flippase (InterPro:IPR006539), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: ATPase E1-E2 type family protein / haloacid dehalogenase-like hydrolase family protein (TAIR:AT1G17500.1); Has 12776 Blast hits to 11290 proteins in 1545 species: Archae - 148; Bacteria - 4231; Metazoa - 2905; Fungi - 2108; Plants - 937; Viruses - 1; Other Eukaryotes - 2446 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    22011305..22020386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_104675.3 → NP_176191.1  aminophospholipid ATPase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176191.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RWQ3, Q9XIE6
    UniProtKB/TrEMBL
    A0A178WFR7, A0A5S9WR14
    Conserved Domains (1) summary
    TIGR01652
    Location:51 → 1129
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XIE6.2

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