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E1 ALPHA pyruvate dehydrogenase complex E1 alpha subunit [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842284, updated on 18-Sep-2024

Summary

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Official Symbol
E1 ALPHA
Official Full Name
pyruvate dehydrogenase complex E1 alpha subunit
Primary source
TAIR:AT1G59900
Locus tag
AT1G59900
See related
Araport:AT1G59900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AT-E1 ALPHA; pyruvate dehydrogenase complex E1 alpha subunit; PYRUVATE DEHYDROGENASE E1 ALPHA SUBUNIT
Summary
encodes the e1 alpha subunit of the pyruvate dehydrogenase complex (PDC)
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Genomic context

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See E1 ALPHA in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Sequence:
Chromosome: 1; NC_003070.9 (22051133..22053885)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SIN3-like 5 Neighboring gene Actin-binding FH2 (formin homology 2) family protein Neighboring gene MADS-box family protein Neighboring gene MADS-box family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Leaf proteome responses of Arabidopsis thaliana exposed to mild cadmium stress. Semane B, et al. J Plant Physiol, 2010 Mar 1. PMID 20005002
  2. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
  3. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
  4. Analysis of the Arabidopsis mitochondrial proteome. Millar AH, et al. Plant Physiol, 2001 Dec. PMID 11743115, Free PMC Article
  5. Proteomic analysis of the 26S proteasome reveals its direct interaction with transit peptides of plastid protein precursors for their degradation. Sako K, et al. J Proteome Res, 2014 Jul 3. PMID 24846764

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001333870.1
NM_104682.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
pyruvate dehydrogenase complex E1 alpha subunit
NP_176198.1
  • pyruvate dehydrogenase complex E1 alpha subunit (E1 ALPHA); FUNCTIONS IN: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, pyruvate dehydrogenase (acetyl-transferring) activity; INVOLVED IN: response to cadmium ion, metabolic process; LOCATED IN: cytosol, mitochondrion, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Dehydrogenase, E1 component (InterPro:IPR001017), Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y (InterPro:IPR017597); BEST Arabidopsis thaliana protein match is: Thiamin diphosphate-binding fold (THDP-binding) superfamily protein (TAIR:AT1G24180.1); Has 9893 Blast hits to 9890 proteins in 1845 species: Archae - 125; Bacteria - 6023; Metazoa - 522; Fungi - 292; Plants - 213; Viruses - 0; Other Eukaryotes - 2718 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    22051133..22053885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_104682.3 → NP_176198.1  pyruvate dehydrogenase complex E1 alpha subunit [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176198.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52901, Q9C5E3, Q9SXC2
    UniProtKB/TrEMBL
    A0A178WNY2, A0A5S9WR07
    Conserved Domains (1) summary
    PLN02269
    Location:28 → 389
    PLN02269; Pyruvate dehydrogenase E1 component subunit alpha

  2. NM_001333870.1 → NP_001321393.1  pyruvate dehydrogenase complex E1 alpha subunit [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AQS2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52901.2

Gene LinkOut

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