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SLAH1 SLAC1 homologue 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842525, updated on 18-Sep-2024

Summary

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Official Symbol
SLAH1
Official Full Name
SLAC1 homologue 1
Primary source
TAIR:AT1G62280
Locus tag
AT1G62280
See related
Araport:AT1G62280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F19K23.20; F19K23_20; SLAC1 homologue 1
Summary
Encodes a protein with ten predicted transmembrane helices. The SLAH1 protein has similarity to the SLAC1 protein involved in ion homeostasis in guard cells. Although it is not expressed in guard cells, it can complement a slac1-2 mutant suggesting that it performs a similar function. SLAH1:GFP localizes to the plasma membrane.
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Genomic context

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See SLAH1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
2
Sequence:
Chromosome: 1; NC_003070.9 (23007044..23008610, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene ncRNA Neighboring gene Saposin-like aspartyl protease family protein Neighboring gene WRKY family transcription factor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SLAH1, a homologue of the slow type anion channel SLAC1, modulates shoot Cl- accumulation and salt tolerance in Arabidopsis thaliana. Qiu J, et al. J Exp Bot, 2016 Aug. PMID 27340232, Free PMC Article
  2. Silent S-Type Anion Channel Subunit SLAH1 Gates SLAH3 Open for Chloride Root-to-Shoot Translocation. Cubero-Font P, et al. Curr Biol, 2016 Aug 22. PMID 27397895
  3. CO2 regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells. Negi J, et al. Nature, 2008 Mar 27. PMID 18305482
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The AtSLAH1 gene is expressed in the root xylem-pole pericycle, where it co-localizes with AtSLAH3. Under high soil salinity, AtSLAH1 expression markedly declined and the chloride content of the xylem sap in AtSLAH1 loss-of-function mutants was half of the wild-type level only. S
    Title: Silent S-Type Anion Channel Subunit SLAH1 Gates SLAH3 Open for Chloride Root-to-Shoot Translocation.
  2. modulates shoot Cl- accumulation and salt tolerance
    Title: SLAH1, a homologue of the slow type anion channel SLAC1, modulates shoot Cl- accumulation and salt tolerance in Arabidopsis thaliana.
  3. AtSLAH1 has a role in controlling root-to-shoot Cl- transport. [AtSLAH1]
    Title: SLAH1, a homologue of the slow type anion channel SLAC1, modulates shoot Cl- accumulation and salt tolerance in Arabidopsis thaliana.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_104908.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables voltage-gated monoatomic anion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chloride transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular monoatomic ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SLAC1 homologue 1
NP_176418.2
  • SLAC1 homologue 1 (SLAH1); CONTAINS InterPro DOMAIN/s: C4-dicarboxylate transporter/malic acid transport protein (InterPro:IPR004695); BEST Arabidopsis thaliana protein match is: SLAC1 homologue 4 (TAIR:AT1G62262.1); Has 719 Blast hits to 716 proteins in 282 species: Archae - 2; Bacteria - 524; Metazoa - 0; Fungi - 6; Plants - 154; Viruses - 0; Other Eukaryotes - 33 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    23007044..23008610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_104908.4 → NP_176418.2  SLAC1 homologue 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176418.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04592, Q5E930, Q84WB2
    UniProtKB/TrEMBL
    A0A178W8P4, A0A5S9WNM6, A0A654EKA2
    Conserved Domains (1) summary
    cd09323
    Location:41 → 350
    TDT_SLAC1_like; Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5E930.1

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