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4CL3 4-coumarate:CoA ligase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842814, updated on 18-Sep-2024

Summary

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Official Symbol
4CL3
Official Full Name
4-coumarate:CoA ligase 3
Primary source
TAIR:AT1G65060
Locus tag
AT1G65060
See related
Araport:AT1G65060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
4-COUMARATE:COA LIGASE; 4-coumarate:CoA ligase 3; F16G16.6; F16G16_6
Summary
encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. mRNA levels are not induced in response to wounding or to fungal infection by P. parasitica. mRNA is expressed in flowers, to a lesser degree in mature leaves and siliques and marginally in seedling roots and bolting stems of mature plants. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, cinnamic acid and 5-OH-ferulic acid. At4CL3 was unable to use sinapic acid as substrate.
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Genomic context

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See 4CL3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Sequence:
Chromosome: 1; NC_003070.9 (24167202..24171635, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene TRAF-like superfamily protein Neighboring gene DNA mismatch repair protein MutS, type 2 Neighboring gene Membrane insertion protein, OxaA/YidC with tetratricopeptide repeat domain-containing protein Neighboring gene nucleolin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Three 4-coumarate:coenzyme A ligases in Arabidopsis thaliana represent two evolutionarily divergent classes in angiosperms. Ehlting J, et al. Plant J, 1999 Jul. PMID 10417722
  2. A large-scale genetic screen in Arabidopsis to identify genes involved in pollen exine production. Dobritsa AA, et al. Plant Physiol, 2011 Oct. PMID 21849515, Free PMC Article
  3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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NM_105180.4
NM_179513.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 4-coumarate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in defense response to fungus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within phenylpropanoid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within pollen exine formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to UV IEP
Inferred from Expression Pattern
more info
 PubMed 
NOT involved_in response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
4-coumarate:CoA ligase 3
NP_176686.1
  • 4-coumarate:CoA ligase 3 (4CL3); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 85516 Blast hits to 77968 proteins in 3765 species: Archae - 1155; Bacteria - 54010; Metazoa - 3516; Fungi - 4668; Plants - 2834; Viruses - 1; Other Eukaryotes - 19332 (source: NCBI BLink).
NP_849844.1
  • 4-coumarate:CoA ligase 3 (4CL3); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 78268 Blast hits to 71395 proteins in 3651 species: Archae - 1111; Bacteria - 51774; Metazoa - 3299; Fungi - 4373; Plants - 2538; Viruses - 1; Other Eukaryotes - 15172 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    24167202..24171635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_105180.4 → NP_176686.1  4-coumarate:CoA ligase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176686.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93Z69, Q9S777
    UniProtKB/TrEMBL
    A0A654EL36, A0A7G2E2V1
    Conserved Domains (1) summary
    PLN02246
    Location:26 → 561
    PLN02246; 4-coumarate--CoA ligase

  2. NM_179513.2 → NP_849844.1  4-coumarate:CoA ligase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2E2V1, F4I9T8
    Conserved Domains (2) summary
    pfam00501
    Location:63 → 465
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:44 → 473
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9S777.1

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