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GSR2 uncharacterized protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 842935, updated on 18-Sep-2024

Summary

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Official Symbol
GSR2
Official Full Name
uncharacterized protein
Primary source
TAIR:AT1G66200
Locus tag
AT1G66200
See related
Araport:AT1G66200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATGSR2; F15E12.14; F15E12_14; GLN1;2; glutamine synthase clone F11; GLUTAMINE SYNTHETASE; glutamine synthetase 1;2
Summary
encodes a cytosolic glutamate synthetase, this enzyme has low affinity with substrate ammonium
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Genomic context

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See GSR2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Sequence:
Chromosome: 1; NC_003070.9 (24655115..24657703, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Eukaryotic aspartyl protease family protein Neighboring gene uncharacterized protein Neighboring gene Subtilisin-like serine endopeptidase family protein Neighboring gene Subtilase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinetic commitment in the catalysis of glutamine synthesis by GS1 from Arabidopsis using (14)N/(15)N and solvent isotope effects. Mauve C, et al. Plant Physiol Biochem, 2016 Nov. PMID 27448794
  2. The cytosolic glutamine synthetase GLN1;2 plays a role in the control of plant growth and ammonium homeostasis in Arabidopsis rosettes when nitrate supply is not limiting. Lothier J, et al. J Exp Bot, 2011 Feb. PMID 20959627
  3. Cytosolic Glutamine Synthetase Gln1;2 Is the Main Isozyme Contributing to GS1 Activity and Can Be Up-Regulated to Relieve Ammonium Toxicity. Guan M, et al. Plant Physiol, 2016 Jul. PMID 27231101, Free PMC Article
  4. Three cytosolic glutamine synthetase isoforms localized in different-order veins act together for N remobilization and seed filling in Arabidopsis. Moison M, et al. J Exp Bot, 2018 Aug 14. PMID 29873769, Free PMC Article
  5. Carbon and amino acids reciprocally modulate the expression of glutamine synthetase in Arabidopsis. Oliveira IC, et al. Plant Physiol, 1999 Sep. PMID 10482686, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glutamine biosynthesis for N-remobilization occurs in veins of all orders (major and minor) in leaves, it is mainly catalysed by the three major GS1 isoforms (GLN1;1, GLN1;2, and GLN1;3), and it is alternatively supported by AS2 in the veins and GS2 in the mesophyll cells.
    Title: Three cytosolic glutamine synthetase isoforms localized in different-order veins act together for N remobilization and seed filling in Arabidopsis.
  2. GLN1;2 is the main isozyme contributing to shoot GS1 activity in vegetative growth stages and can be up-regulated to relieve ammonium toxicity.
    Title: Cytosolic Glutamine Synthetase Gln1;2 Is the Main Isozyme Contributing to GS1 Activity and Can Be Up-Regulated to Relieve Ammonium Toxicity.
  3. GLN1;2 catalysis reaction and kinetics
    Title: Kinetic commitment in the catalysis of glutamine synthesis by GS1 from Arabidopsis using (14)N/(15)N and solvent isotope effects.
  4. GLN1;2 (At1g66200) is essential for nitrogen assimilation under ample nitrate supply and for ammonium detoxification.
    Title: The cytosolic glutamine synthetase GLN1;2 plays a role in the control of plant growth and ammonium homeostasis in Arabidopsis rosettes when nitrate supply is not limiting.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036163.2
NM_001198398.1
NM_105291.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables copper ion binding HDA PubMed 
enables glutamine synthetase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamine synthetase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables salicylic acid binding HDA PubMed 
Process Evidence Code Pubs
involved_in glutamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nitrate assimilation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosolic ribosome HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in plant-type vacuole HDA PubMed 

General protein information

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Preferred Names
uncharacterized protein
NP_001031240.1
  • glutamine synthase clone F11 (GSR2); FUNCTIONS IN: glutamate-ammonia ligase activity, copper ion binding; INVOLVED IN: nitrate assimilation, response to fructose stimulus, response to salt stress, response to sucrose stimulus, response to glucose stimulus; LOCATED IN: cytosol, cytosolic ribosome, apoplast, vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone R1 (TAIR:AT5G37600.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001185327.1
  • glutamine synthase clone F11 (GSR2); CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone R1 (TAIR:AT5G37600.1).
NP_176794.1
  • glutamine synthase clone F11 (GSR2); FUNCTIONS IN: glutamate-ammonia ligase activity, copper ion binding; INVOLVED IN: nitrate assimilation, response to fructose stimulus, response to salt stress, response to sucrose stimulus, response to glucose stimulus; LOCATED IN: cytosol, cytosolic ribosome, apoplast, vacuole, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone R1 (TAIR:AT5G37600.1); Has 11094 Blast hits to 11090 proteins in 3405 species: Archae - 162; Bacteria - 5924; Metazoa - 440; Fungi - 257; Plants - 1757; Viruses - 3; Other Eukaryotes - 2551 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    24655115..24657703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_105291.4 → NP_176794.1  uncharacterized protein AT1G66200 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176794.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LCE1, Q9C8C7
    UniProtKB/TrEMBL
    A0A178W9R9, A0A5S9WSB2, Q0WWL2
    Conserved Domains (1) summary
    PLN02284
    Location:1 → 354
    PLN02284; glutamine synthetase

  2. NM_001036163.2 → NP_001031240.1  uncharacterized protein AT1G66200 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031240.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0Z2C2, F4ID92
    Conserved Domains (2) summary
    pfam00120
    Location:127 → 251
    Gln-synt_C; Glutamine synthetase, catalytic domain
    pfam03951
    Location:22 → 97
    Gln-synt_N; Glutamine synthetase, beta-Grasp domain

  3. NM_001198398.1 → NP_001185327.1  uncharacterized protein AT1G66200 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185327.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4ID91, Q0WWL2
    Conserved Domains (3) summary
    PLN02284
    Location:1 → 363
    PLN02284; glutamine synthetase
    pfam00120
    Location:136 → 357
    Gln-synt_C; Glutamine synthetase, catalytic domain
    pfam03951
    Location:22 → 106
    Gln-synt_N; Glutamine synthetase, beta-Grasp domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LCE1.2

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