ATX1 homolog of anti-oxidant 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ATX1
Official Full Name: homolog of anti-oxidant 1
Primary source: TAIR:AT1G66240
Locus tag: AT1G66240
See related: Araport:AT1G66240
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATATX1; homolog of anti-oxidant 1; T6J19.6; T6J19_6
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Genomic context

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See ATX1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (24686114..24687417, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATX1 plays an essential role in copper (Cu) homeostasis in conferring tolerance to excess Cu and Cu deficiency.
Title: Copper chaperone antioxidant protein1 is essential for copper homeostasis.
Both classes of H3K4 methylases, atx1 and atxr7, appear to be required for proper regulation of FLC expression.
Title: ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001160981.2

Supported by ESTs:

NM_001198399.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in secretory vesicle	HDA more info	PubMed

General protein information

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Preferred Names: homolog of anti-oxidant 1

NP_001154453.1

homolog of anti-oxidant 1 (ATX1); FUNCTIONS IN: metal ion binding; INVOLVED IN: metal ion transport; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121); BEST Arabidopsis thaliana protein match is: copper chaperone (TAIR:AT3G56240.1); Has 1418 Blast hits to 1416 proteins in 230 species: Archae - 2; Bacteria - 113; Metazoa - 138; Fungi - 209; Plants - 939; Viruses - 0; Other Eukaryotes - 17 (source: NCBI BLink).

NP_001185328.1

homolog of anti-oxidant 1 (ATX1); LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages.

NP_564870.1

homolog of anti-oxidant 1 (ATX1); FUNCTIONS IN: metal ion binding; INVOLVED IN: metal ion transport; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121); BEST Arabidopsis thaliana protein match is: copper chaperone (TAIR:AT3G56240.1); Has 1720 Blast hits to 1673 proteins in 288 species: Archae - 4; Bacteria - 215; Metazoa - 140; Fungi - 221; Plants - 1117; Viruses - 0; Other Eukaryotes - 23 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

24686114..24687417 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105295.4 → NP_564870.1 homolog of anti-oxidant 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564870.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94BT9

Conserved Domains (1) summary

cd00371
Location:36 → 93

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
NM_001198399.1 → NP_001185328.1 homolog of anti-oxidant 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001185328.1

Status: REVIEWED

UniProtKB/TrEMBL

F4ID99
NM_001160981.2 → NP_001154453.1 homolog of anti-oxidant 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001154453.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C0Z3B8, Q94BT9, Q9C7U6

UniProtKB/TrEMBL

A0A5S9WSJ8, A0A654ERK7, A0A7G2E3N6

Conserved Domains (1) summary

cd00371
Location:1 → 53

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...