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DIN9 Mannose-6-phosphate isomerase, type I [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843027, updated on 18-Sep-2024

Summary

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Official Symbol
DIN9
Official Full Name
Mannose-6-phosphate isomerase, type I
Primary source
TAIR:AT1G67070
Locus tag
AT1G67070
See related
Araport:AT1G67070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DARK INDUCIBLE 9; F1O19.12; F1O19_12; PHOSPHOMANNOSE ISOMERASE 2; PMI2
Summary
Encodes a protein with phosphomannose isomerase activity that is involved in synthesis of ascorbic acid. Expression is induced after 24 hours of dark treatment, in senescing leaves and treatment with exogenous photosynthesis inhibitor. Induction of gene expression was suppressed in excised leaves supplied with sugar. The authors suggest that the gene's expression pattern is responding to the level of sugar in the cell.
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Genomic context

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See DIN9 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Sequence:
Chromosome: 1; NC_003070.9 (25041833..25044659)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene peptidase M50B-like protein Neighboring gene abscisic acid (aba)-deficient 4 Neighboring gene ribulose bisphosphate carboxylase small chain 1A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Response to darkness of late-responsive dark-inducible genes is positively regulated by leaf age and negatively regulated by calmodulin-antagonist-sensitive signalling in Arabidopsis thaliana. Fujiki Y, et al. Plant Cell Physiol, 2005 Oct. PMID 16100230
  2. Dark-inducible genes from Arabidopsis thaliana are associated with leaf senescence and repressed by sugars. Fujiki Y, et al. Physiol Plant, 2001 Mar. PMID 11240919
  3. Arabidopsis phosphomannose isomerase 1, but not phosphomannose isomerase 2, is essential for ascorbic acid biosynthesis. Maruta T, et al. J Biol Chem, 2008 Oct 24. PMID 18755683, Free PMC Article
  4. Multiple signaling pathways in gene expression during sugar starvation. Pharmacological analysis of din gene expression in suspension-cultured cells of Arabidopsis. Fujiki Y, et al. Plant Physiol, 2000 Nov. PMID 11080291, Free PMC Article
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

NM_001334269.1
NM_001334270.1
NM_105377.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mannose-6-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mannose-6-phosphate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-ascorbic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to DDT IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to absence of light IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to sucrose IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to zinc ion IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Mannose-6-phosphate isomerase, type I
NP_001319330.1
  • DARK INDUCIBLE 9 (DIN9); CONTAINS InterPro DOMAIN/s: Mannose-6-phosphate isomerase (InterPro:IPR016305), Cupin, RmlC-type (InterPro:IPR011051), Mannose-6-phosphate isomerase, type I (InterPro:IPR001250), RmlC-like jelly roll fold (InterPro:IPR014710), Phosphomannose isomerase, type I, conserved site (InterPro:IPR018050); BEST Arabidopsis thaliana protein match is: Mannose-6-phosphate isomerase, type I (TAIR:AT3G02570.1); Has 2340 Blast hits to 2321 proteins in 789 species: Archae - 2; Bacteria - 1171; Metazoa - 570; Fungi - 215; Plants - 90; Viruses - 0; Other Eukaryotes - 292 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    25041833..25044659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001334269.1 → NP_001319330.1  Mannose-6-phosphate isomerase, type I [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q67YT4, Q9FVM3, Q9FZH5
    UniProtKB/TrEMBL
    A0A178WK67, A0A5S9WQH3
    Conserved Domains (1) summary
    PLN02288
    Location:22 → 419
    PLN02288; mannose-6-phosphate isomerase

  2. NM_105377.5 → NP_176878.1  Mannose-6-phosphate isomerase, type I [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176878.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q67YT4, Q9FVM3, Q9FZH5
    UniProtKB/TrEMBL
    A0A178WK67, A0A5S9WQH3
    Conserved Domains (1) summary
    PLN02288
    Location:22 → 419
    PLN02288; mannose-6-phosphate isomerase

  3. NM_001334270.1 → NP_001321710.1  Mannose-6-phosphate isomerase, type I [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8ARS3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FZH5.1

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