U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GCS1 glucosidase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843070, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
GCS1
Official Full Name
glucosidase 1
Primary source
TAIR:AT1G67490
Locus tag
AT1G67490
See related
Araport:AT1G67490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
glucosidase 1; KNF; KNOPF; T1F15.4; T1F15_4
Summary
Encodes an alpha-glucosidase I enzyme that catalyzes the first step in N-linked glycan processing. Localized to the endoplasmic reticulum (ER).
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GCS1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
22
Sequence:
Chromosome: 1; NC_003070.9 (25280410..25286749, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene ncRNA Neighboring gene microRNA ath-MIR839 precursor Neighboring gene recovery protein 3 Neighboring gene Leucine-rich repeat protein kinase family protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cytosolic N-terminal arginine-based signals together with a luminal signal target a type II membrane protein to the plant ER. Boulaflous A, et al. BMC Plant Biol, 2009 Dec 8. PMID 19995436, Free PMC Article
  2. A novel mutation in KNOPF uncovers the role of alpha-glucosidase I during post-embryonic development in Arabidopsis thaliana. Furumizu C, et al. FEBS Lett, 2008 Jun 25. PMID 18503769
  3. Plant N-glycan processing enzymes employ different targeting mechanisms for their spatial arrangement along the secretory pathway. Saint-Jore-Dupas C, et al. Plant Cell, 2006 Nov. PMID 17138701, Free PMC Article
  4. Alpha-glucosidase I is required for cellulose biosynthesis and morphogenesis in Arabidopsis. Gillmor CS, et al. J Cell Biol, 2002 Mar 18. PMID 11901167, Free PMC Article
  5. Arabidopsis glucosidase I mutants reveal a critical role of N-glycan trimming in seed development. Boisson M, et al. EMBO J, 2001 Mar 1. PMID 11230125, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arginine residues in the cytosolic tail of AtGCSI contain ER localization information.
    Title: Cytosolic N-terminal arginine-based signals together with a luminal signal target a type II membrane protein to the plant ER.
  2. knf-101 mutation alters cell shape but does not affect cell arrangements, except for the patterning of specialized epidermal cells, delineating the significance of N-glycan processing during epidermal development in Arabidopsis.
    Title: A novel mutation in KNOPF uncovers the role of alpha-glucosidase I during post-embryonic development in Arabidopsis thaliana.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help
NM_001036170.1
NM_105416.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-1,4-glucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,4-glucosidase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in oligosaccharide metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within plant epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_negative_effect protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within root epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
glucosidase 1
NP_001031247.1
  • glucosidase 1 (GCS1); FUNCTIONS IN: alpha-glucosidase activity; INVOLVED IN: root epidermal cell differentiation, epidermal cell differentiation; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 63 (InterPro:IPR004888), Six-hairpin glycosidase-like (InterPro:IPR008928); BEST Arabidopsis thaliana protein match is: Six-hairpin glycosidases superfamily protein (TAIR:AT1G24320.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_176916.2
  • glucosidase 1 (GCS1); FUNCTIONS IN: alpha-glucosidase activity; INVOLVED IN: root epidermal cell differentiation, epidermal cell differentiation; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 63 (InterPro:IPR004888), Six-hairpin glycosidase-like (InterPro:IPR008928); BEST Arabidopsis thaliana protein match is: Six-hairpin glycosidases superfamily protein (TAIR:AT1G24320.1); Has 477 Blast hits to 469 proteins in 208 species: Archae - 2; Bacteria - 128; Metazoa - 110; Fungi - 127; Plants - 43; Viruses - 0; Other Eukaryotes - 67 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    25280410..25286749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_105416.5 → NP_176916.2  glucosidase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176916.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4HTM2, F4HTM3, O64796, Q8GWC8, Q940D4, Q9C5B4, Q9CAG7
    UniProtKB/TrEMBL
    A0A5S9WSJ5
    Conserved Domains (2) summary
    pfam03200
    Location:348 → 847
    Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
    pfam16923
    Location:109 → 274
    Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

  2. NM_001036170.1 → NP_001031247.1  glucosidase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031247.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9WSJ5
    Conserved Domains (2) summary
    pfam03200
    Location:264 → 763
    Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
    pfam16923
    Location:109 → 126
    Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4HTM3.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.