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PIS1 phosphatidylinositol synthase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 843128, updated on 18-Sep-2024

Summary

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Official Symbol
PIS1
Official Full Name
phosphatidylinositol synthase 1
Primary source
TAIR:AT1G68000
Locus tag
AT1G68000
See related
Araport:AT1G68000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATPIS; ATPIS1; PHOSPHATIDYLINOSITOL SYNTHASE; phosphatidylinositol synthase 1; T23K23.15; T23K23_15
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Genomic context

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See PIS1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Sequence:
Chromosome: 1; NC_003070.9 (25490911..25493077)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene caffeoyl-CoA 3-O-methyltransferase Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene hydroxypyruvate reductase Neighboring gene UDP-Glycosyltransferase / trehalose-phosphatase family protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of AtPIS, a phosphatidylinositol synthase from Arabidopsis. Collin S, et al. Eur J Biochem, 1999 Jun. PMID 10411624
  2. Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H(+)-ATPase and Na(+)/H(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress. Yang Y, et al. Mol Plant, 2021 Dec 6. PMID 34339895
  3. Alternative metabolic fates of phosphatidylinositol produced by phosphatidylinositol synthase isoforms in Arabidopsis thaliana. Löfke C, et al. Biochem J, 2008 Jul 1. PMID 18402553
  4. Cloning of Arabidopsis thaliana phosphatidylinositol synthase and functional expression in the yeast pis mutant. Xue HW, et al. Plant Mol Biol, 2000 Mar. PMID 10809447
  5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H(+)-ATPase and Na(+)/H(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress.
    Title: Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H(+)-ATPase and Na(+)/H(+) antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_105470.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within phospholipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol synthase 1
NP_176967.1
  • phosphatidylinositol synthase 1 (PIS1); CONTAINS InterPro DOMAIN/s: CDP-alcohol phosphatidyltransferase (InterPro:IPR000462), CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote (InterPro:IPR014387); BEST Arabidopsis thaliana protein match is: probable CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2 (TAIR:AT4G38570.1); Has 2907 Blast hits to 2907 proteins in 1088 species: Archae - 25; Bacteria - 1785; Metazoa - 167; Fungi - 194; Plants - 81; Viruses - 0; Other Eukaryotes - 655 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    25490911..25493077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_105470.3 → NP_176967.1  phosphatidylinositol synthase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_176967.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81846, Q8LBA6
    UniProtKB/TrEMBL
    A0A178WC27, A0A5S9WSN1
    Conserved Domains (1) summary
    COG0558
    Location:6 → 126
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LBA6.2

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